Antibiotic Lock Solutions in the Prevention of Catheter Related Bacteremia

Phase 4 Completed 120 enrolled Henry Ford Health System

RandomizedSingle-groupOpen-labelPrevention

Summary

To study the efficacy of an antibacterial/anticoagulant solution instilled into the hemodialysis (HD) catheters after each treatment ("antibiotic lock solution - ALS") to prevent catheter related bacteremia (CRB) and to salvage catheters with established CRB.

Timeline

Start: 2003-09
Primary completion: —
Completion: 2004-05

Outcome

Met primary endpoint

paper Infection rates per 100 catheter-days were 0.03 in the gentamicin group versus 0.42 in the heparin group (P = 0.003). PMID 12138146 ↗

Publications

Results Allon M. Dialysis catheter-related bacteremia: treatment and prophylaxis. Am J Kidney Dis. 2004 Nov;44(5):779-91.
Results Dogra GK, Herson H, Hutchison B, Irish AB, Heath CH, Golledge C, Luxton G, Moody H. Prevention of tunneled hemodialysis catheter-related infections using catheter-restricted filling with gentamicin and citrate: a randomized controlled study. J Am Soc Nephrol. 2002 Aug;13(8):2133-9. doi: 10.1097/01.asn.0000022890.29656.22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	EDTA	Unknown	—	Other
Subject	Gentamicin	Small molecule	—	Other
Subject	Minocycline	Small molecule	—	Other
Subject	citrate	Unknown	—	Other