drugset / Trial / NCT03801629
Neuroimmune Effects of Opioid Administration
Non-randomizedParallel-groupSingle-blindBasic science
Summary
Preclinical research indicates acute opioid administration evokes an immune response in the periphery and brain. Here, we will translate those preclinical findings to healthy human volunteers and quantify the neuroimmune response to a morphine challenge using positron emission tomography (PET) imaging with \[11C\]PBR28.
Timeline
- Start
- 2019-09-12
- Primary completion
- 2021-03-10
- Completion
- 2021-03-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Morphine | Other / unclassified | 0.04 mg/kg | Intramuscular |
| Subject | Morphine | Other / unclassified | 0.07 mg/kg | Intramuscular |
| Background | Metoclopramide | Small molecule | 10 mg | Oral |
Indications
No indication recorded.