Haloperidol Prophylaxis in Older Emergency Department Patients

Summary

The investigators propose a multicenter, randomized, double-blinded, placebo-controlled trial to study the effect of additive low-dose haloperidol prophylaxis on top of exciting care in a general population of older patients (age 70 years and over) acutely admitted to the hospital through the emergency department (ED) for general medicine and surgical specialties, and who are at-risk for developing in-hospital delirium on admission according to the VMS delirium risk questions (one or more positive answers out of three questions). The investigators hypothesize that this intervention will reduce the incidence of in-hospital delirium as well as duration and severity of delirium.

Timeline

Start

2012-11

Primary completion

2015-04

Completion

2015-10

Publications

• Schrijver EJ, de Vries OJ, Verburg A, de Graaf K, Bet PM, van de Ven PM, Kamper AM, Diepeveen SH, Anten S, Siegel A, Kuiperi E, Lagaay AM, van Marum RJ, van Strien AM, Boelaarts L, Pons D, Kramer MH, Nanayakkara PW. Efficacy and safety of haloperidol prophylaxis for delirium prevention in older medical and surgical at-risk patients acutely admitted to hospital through the emergency department: study protocol of a multicenter, randomised, double-blind, placebo-controlled clinical trial. BMC Geriatr. 2014 Aug 28;14:96. doi: 10.1186/1471-2318-14-96.

Drugs

Indications