Rapid Agitation Control With Ketamine in the Emergency Department

Phase 2 Completed 81 enrolled David Barbic Centre for Health Evaluation and Outcome Sciences (CHÉOS) · collab St Paul's Emergency Department Research Fund · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Compare intramuscular (IM) ketamine to a combination of IM midazolam and haloperidol with regards to the time required for adequate behavioral control, in minutes, in patients presenting to the emergency department with psychomotor agitation and violent behavior.

Timeline

Start: 2018-05-29
Primary completion: 2020-03-12
Completion: 2020-03-12

Publications

Barbic D, Andolfatto G, Grunau B, Scheuermeyer FX, MacEwan W, Honer WG, Wong H, Barbic SP. Rapid agitation control with ketamine in the emergency department (RACKED): a randomized controlled trial protocol. Trials. 2018 Nov 26;19(1):651. doi: 10.1186/s13063-018-2992-x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Haloperidol	Other / unclassified	5 mg	Intramuscular
Subject	Ketamine	Small molecule	5 mg/kg	Intramuscular
Comparator	Midazolam	Small molecule	5 mg	Intramuscular

Indications

No indication recorded.