drugset / Trial / NCT00954603
A Double-blind, Randomized, Controlled Trial of Quetiapine Versus Haloperidol for the Treatment of Delirium
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to determine whether quetiapine, and haloperidol are effective and safe in the treatment psychiatric symptoms in patients with delirium.
Timeline
- Start
- 2009-06
- Primary completion
- 2011-04
- Completion
- 2012-07
Outcome
Missed primary endpoint
Stopped (Enrollment): “few delirious patients were enrolled.”
paper DRS-R-98 severity scores were not significantly different between the quetiapine and haloperidol groups (-22.9 [6.9] versus -21.7 [6.7]; P = 0.59). PMID 23926422 ↗
Publications
- Results Maneeton B, Maneeton N, Srisurapanont M. An open-label study of quetiapine for delirium. J Med Assoc Thai. 2007 Oct;90(10):2158-63.
- Maneeton B, Maneeton N, Srisurapanont M, Chittawatanarat K. Quetiapine versus haloperidol in the treatment of delirium: a double-blind, randomized, controlled trial. Drug Des Devel Ther. 2013 Jul 24;7:657-67. doi: 10.2147/DDDT.S45575. Print 2013.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Haloperidol | Other / unclassified | 0.5 mg | — |
| Comparator | Haloperidol | Other / unclassified | 2 mg | — |
| Subject | Quetiapine | Small molecule | 25 mg | — |
| Subject | Quetiapine | Small molecule | 100 mg | — |