drugset / Trial / NCT01016145
Identifying Predictors of Response to Antipsychotics Using a Treatment Algorithm
RandomizedParallel-groupOpen-labelTreatment
Summary
The objective of this study is to evaluate predictors of response to antipsychotic medication in subjects with schizophrenia. The investigators will evaluate psychopathology,brain MRI, genetics and neuropsychological profile. Two groups of treatment will be compared: first generation antipsychotics vs. second generation antipsychotics. Participants will be randomized to one of the groups. Trial duration: 12 weeks.
Timeline
- Start
- 2009-04
- Primary completion
- 2010-06
- Completion
- 2010-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Aripiprazole | Other / unclassified | 15 mg | — |
| Subject | Aripiprazole | Other / unclassified | 30 mg | — |
| Subject | Chlorpromazine | Small molecule | 25 mg | — |
| Subject | Chlorpromazine | Small molecule | 600 mg | — |
| Subject | Haloperidol | Other / unclassified | 2.5 mg | — |
| Subject | Haloperidol | Other / unclassified | 10 mg | — |
| Subject | Olanzapine | Small molecule | 5 mg | — |
| Subject | Olanzapine | Small molecule | 20 mg | — |
| Subject | Quetiapine | Small molecule | 25 mg | — |
| Subject | Quetiapine | Small molecule | 800 mg | — |
| Subject | Risperidone | Other / unclassified | 2 mg | — |
| Subject | Risperidone | Other / unclassified | 8 mg | — |
| Subject | Ziprasidone | Small molecule | 80 mg | — |
| Subject | Ziprasidone | Small molecule | 160 mg | — |