Drugs / Chlorpromazine
Chlorpromazine
also known as
Chlorpromazine Hydrochloride · CPZ · Largactil · Aminazine · Chloractil · Chlorpromazine hcl · Chlorpromazine hydrochloride intensol · Chlorpromazine hydrochloride, Thorazine · +27 more
Small molecule targets DRD2, HTR2A via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | THORAZINE | — | 1957-09-18 | fda.gov ↗ |
Trials 13 · a red edge is where a trial was stopped
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 13 trials | ||||||
| Phase 1 | NCT06663631 | Nov 2024 → Jan 2025 overdue | ischemic stroke | Capital Medical University | Recruiting | No outcome recorded |
| Phase 1 | NCT05190315 | Jan 2022 → Apr 2023 | glioblastoma | Mohammed Milhem | Completed | No outcome recorded |
| Phase 1 | NCT02943213 | Nov → Dec 2016 | acute intermittent porphyria, chronic hiccup, manic bipolar affective disorder, schizophrenia | Cycle Pharmaceuticals Ltd. | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT05433402 | Jul → Sep 2022 | malignant colon neoplasm | Sadat City University | Withdrawn | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT04224441 | Dec 2019 → Jun 2022 | glioblastoma | Marco G Paggi, MD, PhD | Unknown | No outcome recorded |
| Phase 2/33 trials | ||||||
| Phase 2/3 | NCT05431595 | Jul 2022 → Feb 2027 expected | delirium, epilepsy | M.D. Anderson Cancer Center | Recruiting | No outcome recorded |
| Phase 2/3 | NCT04354805 | Aug → Oct 2020 | COVID-19 | Cairo University | Unknown | No outcome recorded |
| Phase 2/3 | NCT03021486 | Jun 2017 → Jun 2021 overdue | delirium, metastatic malignant neoplasm | M.D. Anderson Cancer Center | Active not recruiting | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT04366739 | Apr → Aug 2020 | COVID-19 | Centre Hospitalier St Anne | Withdrawn | No outcome recorded |
| Phase 3 | NCT01765829 | Nov 2012 → Nov 2015 | psychotic disorder | Fundación Pública Andaluza Progreso y Salud | Unknown | No outcome recorded |
| Phase 42 trials | ||||||
| Phase 4 | NCT01016145 | Apr 2009 → Jun 2010 | psychotic disorder | University of Sao Paulo | Unknown | No outcome recorded |
| Phase 4 | NCT00169039 | Dec 1994 → Feb 2002 | schizophrenia | Harvard Medical School (HMS and HSDM) | Terminated | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT07364344 | Jan → Jul 2026 overdue | ischemic stroke | Ji Xunming,MD,PhD | Not yet recruiting | No outcome recorded |
Also used as a comparator or background therapy in 8 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT01323205 Background | May 2011 → Nov 2012 | schizophrenia | Janssen Research & Development, LLC | Completed | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT00882518 Comparator | Apr 2009 → Jul 2010 | schizophrenia | AstraZeneca | Completed | No outcome recorded |
| Phase 3 | NCT02810782 Comparator | Jun 2001 → Dec 2007 | neonatal abstinence syndrome | University of Zurich | Completed | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT03639558 Comparator | Aug 2018 → Jul 2019 | — | Joseph Dib | Completed | No outcome recorded |
| Phase 4 | NCT00654576 Comparator | Feb 2005 → Dec 2007 | schizophrenia | Central South University | Completed | No outcome recorded |
| Phase 4 | NCT00202293 Comparator | Oct 2001 → Nov 2015 | bipolar disorder, schizoaffective disorder | Melbourne Health | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT03183310 Comparator | Jul → Oct 2017 | gastroesophageal reflux disease | Universitaire Ziekenhuizen KU Leuven | Unknown | No outcome recorded |
| — | NCT01404364 Comparator | Jan → Dec 2010 | glaucoma, visual impairment and progressive phthisis bulbi | Hospital Governador Celso Ramos | Completed | No outcome recorded |
Evidence & citations 41 cited values
Every value below carries the sentence it was read from. 22 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Chlorpromazine | “Drugs: Aripiprazole, Olanzapine, Zuclopenthixol, Clotiapine, Flupentixol, Risperidone, Sulpiride, Trifluoperazine, Haloperidol, Quetiapine, Paliperidone, Chlorpromazine,...” NCT01765829 ↗ |
| Known as | Aminazine | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Chloractil | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Chlorpromazine hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Chlorpromazine Hydrochloride | “Regular antipsychotic medications (Risperidone, Olanzapine, Clozapine, Amisulpride, Quetiapine, Paliperidone, Aripiprazole, Haloperidol, Levomepromazine, Zuclopenthixol...” NCT01323205 ↗ |
| Known as | Chlorpromazine hydrochloride intensol | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Chlorpromazine hydrochloride, Thorazine | “Chlorpromazine hydrochloride, Thorazine®” NCT05431595 ↗ |
| Known as | Chlorpromazini hydrochloridum | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Chlorpromazinum | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Clorpromazina | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | CPZ | “Chlorpromazine (CPZ, Largactil, Thorazine) is a potent antagonist of the dopamine receptor D2 (DRD2) and has been effectively and safely employed for over half a century in the...” NCT04224441 ↗1“CHLORPROMAZINE (CPZ)” NCT04366739 ↗ |
| Known as | Elmarin | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Esmind | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Fenactil | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | J2.794D | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Klorproman | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Largactil | “Chlorpromazine (CPZ, Largactil, Thorazine) is a potent antagonist of the dopamine receptor D2 (DRD2) and has been effectively and safely employed for over half a century in the...” NCT04224441 ↗1“The effect of chlorpromazine (Largactil) on esophageal sensitivity will be investigated in this study.” NCT03183310 ↗ |
| Known as | Largactil fte | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Largactilothiazine | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Marazine | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Megaphen | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Nci-c05210 | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Norcozine | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Novomazina | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | NSC-167745 | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | NSC-17479 | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | NSC-226514 | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Promapar | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Propaphenin | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Rimazine | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Sanopron | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | SKF-2601A | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Sonazine | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Known as | Thorazine | “Chlorpromazine (CPZ, Largactil, Thorazine) is a potent antagonist of the dopamine receptor D2 (DRD2) and has been effectively and safely employed for over half a century in the...” NCT04224441 ↗ |
| Known as | Trade name: Chlorpromazine Hydrochloride 25 mg Tablets, USP | “Trade name: Chlorpromazine Hydrochloride 25 mg Tablets, USP” NCT02943213 ↗ |
| Known as | Wintermin | ChEMBL registry synonym — accepted as the source's own label CHEMBL71 ↗ |
| Action | Inhibit | “potent antagonist of the dopamine receptor D2 (DRD2)” NCT04224441 ↗1“Serotonin 2a (5-HT2a) receptor antagonist” CHEMBL71 ↗ |
| Modality | Small molecule | — CHEMBL71 ↗ |
| Route | Oral | “Chlorpromazine will be started at 100 mg/day orally” NCT00202293 ↗ |
| Target | DRD2 | “Chlorpromazine is an antagonist of the dopamine receptor D2 (DRD2)” NCT04354805 ↗ |
| Target | HTR2A | “Serotonin 2a (5-HT2a) receptor antagonist” CHEMBL71 ↗ |