drugset / Trial / NCT00169039
Clozapine Versus Chlorpromazine for Treatment-Unresponsive Schizophrenia
Phase 4
Terminated
66 enrolled
Harvard Medical School (HMS and HSDM)
Commonwealth Research Center, Massachusetts · collabDartmouth-Hitchcock Medical Center · collabNational Institute of Mental Health (NIMH) · collabNovartis · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
This study will examine the physical response to clozapine or chlorpromazine in people with schizophrenia that has not improved with treatment.
Timeline
- Start
- 1994-12
- Primary completion
- —
- Completion
- 2002-02
Publications
- Background Green AI, Alam MY, Boshes RA, Waternaux C, Pappalardo KM, Fitzgibbon ME, Tsuang MT, Schildkraut JJ. Haloperidol response and plasma catecholamines and their metabolites. Schizophr Res. 1993 Jun;10(1):33-7. doi: 10.1016/0920-9964(93)90074-s.
- Background Green AI, Alam MY, Sobieraj JT, Pappalardo KM, Waternaux C, Salzman C, Schatzberg AF, Schildkraut JJ. Clozapine response and plasma catecholamines and their metabolites. Psychiatry Res. 1993 Feb;46(2):139-49. doi: 10.1016/0165-1781(93)90016-a.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Chlorpromazine | Small molecule | — | — |
| Subject | Clozapine | Other / unclassified | — | — |