drugset / Trial / NCT00654576
Effectiveness of Antipsychotic Combination With Psychosocial Intervention on Outcome of Patients With Schizophrenia
Phase 4
Completed
1400 enrolled
Central South University
Capital Medical University · collabChongqing Metal Institute · collabGuangzhou Mental Hospital · collabHenan Mental Hospital · collabHunan Mental Hospital · collabJiangxi Mental Hospital · collabNanjing Medical University · collabShanghai Mental Health Center · collabSichuan University · collab
RandomizedFactorialOpen-labelTreatment
Summary
Antipsychotic alone is limit to improve the overall outcome of schizophrenia and has a high discontinue rate.To solve these problems, we provide practical and available psychosocial intervention. We hypothesize that there will be significant difference in the overall effectiveness between antipsychotic and antipsychotic combination with psychosocial intervention.
Timeline
- Start
- 2005-02
- Primary completion
- 2007-12
- Completion
- 2007-12
Publications
- Zhang Z, Zhai J, Wei Q, Qi J, Guo X, Zhao J. Cost-effectiveness analysis of psychosocial intervention for early stage schizophrenia in China: a randomized, one-year study. BMC Psychiatry. 2014 Jul 26;14:212. doi: 10.1186/s12888-014-0212-0.
- Guo X, Fang M, Zhai J, Wang B, Wang C, Hu B, Sun X, Lv L, Lu Z, Ma C, Guo T, Xie S, Twamley EW, Jin H, Zhao J. Effectiveness of maintenance treatments with atypical and typical antipsychotics in stable schizophrenia with early stage: 1-year naturalistic study. Psychopharmacology (Berl). 2011 Aug;216(4):475-84. doi: 10.1007/s00213-011-2242-3. Epub 2011 Mar 3.
- Guo X, Zhai J, Liu Z, Fang M, Wang B, Wang C, Hu B, Sun X, Lv L, Lu Z, Ma C, He X, Guo T, Xie S, Wu R, Xue Z, Chen J, Twamley EW, Jin H, Zhao J. Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: A randomized, 1-year study. Arch Gen Psychiatry. 2010 Sep;67(9):895-904. doi: 10.1001/archgenpsychiatry.2010.105.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aripiprazole | Other / unclassified | — | — |
| Comparator | Chlorpromazine | Small molecule | — | — |
| Comparator | Clozapine | Other / unclassified | — | — |
| Comparator | Olanzapine | Small molecule | — | — |
| Comparator | Quetiapine | Small molecule | — | — |
| Comparator | Risperidone | Other / unclassified | — | — |
| Comparator | Sulpiride | Small molecule | — | — |