Drugs / Ziprasidone
last change Jan 2026 re-read 2 minutes ago

Ziprasidone

Small molecule targets DRD2, HTR2A, HTR2C via inhibition

Developed for
schizophrenia · bipolar disorder · schizoaffective disorder · psychotic disorder · manic bipolar affective disorder · bipolar I disorder · depressive disorder · major depressive disorder
+20 more · bipolar depression · delirium · generalized anxiety disorder · alcohol dependence · anxiety · autism · bipolar II disorder · conduct disorder · delusional disorder · drug dependence · metabolic syndrome X · mood disorder · oppositional defiant disorder · panic disorder · post-traumatic stress disorder · schizophreniform disorder · social phobia · borderline personality disorder · opiate dependence · opioid abuse
Investigated by
Viatris Inc. · Pfizer · National Institute of Mental Health (NIMH) · Massachusetts General Hospital · Northwell Health · Beijing HuiLongGuan Hospital
+56 more · Bronx Psychiatric Center · Buffalo Psychiatric Center · Central Institute of Mental Health, Mannheim · Centre for Addiction and Mental Health · Chonbuk National University Hospital · Creighton University · Donald C. Goff, MD · Drexel University College of Medicine · Duke University · Eli Lilly and Company · Federal University of Rio Grande do Sul · Fundación Pública Andaluza Progreso y Salud · George Washington University · Guiyun Xu · H. Lundbeck A/S · Hannover Medical School · Hospital de Clinicas de Porto Alegre · Instituto de Salud Carlos III · Liebowitz, Michael R., M.D. · Lindner Center of HOPE · MDS Pharma Services · Manhattan Psychiatric Center · Medical College of Wisconsin · Medical University of Vienna · New York State Psychiatric Institute · North Suffolk Mental Health Association · Providence Health & Services · Queen's University · Rochester Psychiatric Center · Sant Pau Research Institute · Second Affiliated Hospital, School of Medicine, Zhejiang University · Shanghai Jiao Tong University School of Medicine · Shanghai Mental Health Center · Shanxi Medical University · Sidney R. Baer, Jr. Foundation · Solvay Pharmaceuticals · Soonchunhyang University Hospital · Stanford University · Technical University of Munich · The Medical Research Network · The University of Hong Kong · The University of Texas Health Science Center at San Antonio · University Hospital Freiburg · University Hospitals Cleveland Medical Center · University of Alabama at Birmingham · University of Arizona · University of North Carolina, Chapel Hill · University of Sao Paulo · University of South Florida · VA Palo Alto Health Care System · Vanderbilt University Medical Center · Veterans Medical Research Foundation · Washington University School of Medicine · Wyeth is now a wholly owned subsidiary of Pfizer · Yale University · Yang Fude

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (3) US (FDA) GEODON 2004-08-19 – 2022-01-28 fda.gov
Approved US (FDA) GEODON 2001-02-05 fda.gov

Trials 80 · started per year

today
US approved 2001
2
3
8
14
5
5
12
2
7
3
4
2
3
2
1
2
1
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1
1
200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT04587115 Jun 2017 → Jun 2019 drug dependence The University of Texas Health Science Center at San Antonio Completed No outcome recorded
Phase 11 trial
Phase 1 NCT03781115 Nov 2017 → Feb 2027 expected schizophrenia University of Arizona Active not recruiting No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT02650102 Jan 2013 → Dec 2016 schizophrenia Shanxi Medical University Unknown No outcome recorded
Phase 1/2 NCT04975035 Jan → Jul 2012 schizophrenia Second Affiliated Hospital, School of Medicine, Zhejiang University Terminated No outcome recorded
Phase 26 trials
Phase 2 NCT00633399 Jul 2008 → Mar 2014 major depressive disorder Massachusetts General Hospital Completed No outcome recorded
Phase 2 NCT00635700 Mar 2008 → Nov 2012 psychotic disorder Yale University Completed No outcome recorded
Phase 2 NCT00676429 Jul 2006 → Jun 2008 conduct disorder, oppositional defiant disorder University Hospital Freiburg Completed No outcome recorded
Phase 2 NCT00215150 Nov 2004 → Dec 2008 social phobia Duke University Completed No outcome recorded
Phase 2 NCT01006551 Dec 2002 → Feb 2006 schizophrenia University of North Carolina, Chapel Hill Completed No outcome recorded
Phase 2 NCT00208559 Feb 2002 → Jun 2005 autism Drexel University College of Medicine Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00395031 Sep 2003 → Jan 2010 schizoaffective disorder, schizophrenia Manhattan Psychiatric Center Completed No outcome recorded
Phase 328 trials
Phase 3 NCT03768726 Dec 2018 → Jul 2020 bipolar disorder Viatris Inc. Terminated No outcome recorded
Phase 3 NCT02374567 Jan 2015 → Jun 2017 anxiety disorder, dementia, depressive disorder, schizophrenia +1 Hannover Medical School Terminated No outcome recorded
Phase 3 NCT02075047 May 2014 → Apr 2020 bipolar I disorder Viatris Inc. Terminated No outcome recorded
Phase 3 NCT01765829 Nov 2012 → Nov 2015 psychotic disorder Fundación Pública Andaluza Progreso y Salud Unknown No outcome recorded
Phase 3 NCT01211522 Dec 2011 → Aug 2017 delirium, mental disorder Vanderbilt University Medical Center Completed No outcome recorded
Phase 3 NCT01124877 Jul 2010 → Oct 2011 bipolar disorder Viatris Inc. Withdrawn No outcome recorded
Phase 3 NCT01113541 Jul 2010 → Feb 2011 bipolar disorder Viatris Inc. Terminated No outcome recorded
Phase 3 NCT00723606 Sep 2008 → Jul 2009 schizophrenia Viatris Inc. Completed No outcome recorded
Phase 3 NCT00483548 Oct 2007 → Dec 2008 bipolar I disorder, bipolar depression Viatris Inc. Completed No outcome recorded
Phase 3 NCT00347425 Dec 2006 → Feb 2008 schizophrenia Solvay Pharmaceuticals Completed No outcome recorded
Phase 437 trials
Phase 4 NCT04446234 May 2021 → Dec 2022 schizophrenia Shanghai Mental Health Center Unknown No outcome recorded
Phase 4 NCT02935998 Oct 2016 → Dec 2017 schizophrenia Yang Fude Unknown No outcome recorded
Phase 4 NCT02307396 Feb 2015 → Jun 2016 schizoaffective disorder, schizophrenia Technical University of Munich Completed No outcome recorded
Phase 4 NCT01893229 Sep 2013 → Dec 2015 bipolar disorder Guiyun Xu Unknown No outcome recorded
Phase 4 NCT01293825 Jan 2011 → Aug 2012 bipolar disorder University Hospitals Cleveland Medical Center Completed No outcome recorded
Phase 4 NCT01198353 Sep 2010 → Jun 2013 schizoaffective disorder, schizophrenia Soonchunhyang University Hospital Completed No outcome recorded
Phase 4 NCT01172652 Apr 2010 → Oct 2011 bipolar disorder, generalized anxiety disorder, panic disorder VA Palo Alto Health Care System Completed No outcome recorded
Phase 4 NCT01016145 Apr 2009 → Jun 2010 psychotic disorder University of Sao Paulo Unknown No outcome recorded
Phase 4 NCT00835107 Feb 2009 → Jun 2011 bipolar depression Queen's University Completed No outcome recorded
Phase 4 NCT00748566 Dec 2008 → May 2012 psychotic disorder Viatris Inc. Terminated No outcome recorded
Phase not applicable4 trials
NCT04076371 Jan 2012 → Dec 2018 schizophrenia Beijing HuiLongGuan Hospital Completed No outcome recorded
NCT00818298 Jan 2009 → Jan 2011 schizoaffective disorder, schizophrenia Centre for Addiction and Mental Health Completed No outcome recorded
NCT00225498 Jun 2002 → Oct 2008 schizophrenia Northwell Health Completed No outcome recorded
NCT00205725 Nov 2000 → Oct 2006 schizophrenia, type 2 diabetes mellitus Washington University School of Medicine Completed No outcome recorded
Also used as a comparator or background therapy in 46 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03837860 Comparator Apr 2019 → Mar 2021 opiate dependence, opioid abuse The University of Texas Health Science Center at San Antonio Terminated No outcome recorded
Phase 14 trials
Phase 1 NCT03565068 Background Jun 2018 → Apr 2020 schizophrenia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT03011645 Comparator May 2018 → Jan 2020 cardiovascular disorder Duke University Terminated No outcome recorded
Phase 1 NCT02181803 Background Aug 2014 → Apr 2015 schizophrenia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT00821444 Comparator Jan → Mar 2009 Viatris Inc. Completed No outcome recorded
Phase 28 trials
Phase 2 NCT03557931 Background Jul 2018 → Oct 2019 schizophrenia Astellas Pharma Global Development, Inc. Completed No outcome recorded
Phase 2 NCT03319953 Background Dec 2017 → Sep 2019 schizophrenia Neurocrine Biosciences Completed No outcome recorded
Phase 2 NCT00555997 Comparator Mar 2008 → Jun 2010 major depressive disorder Massachusetts General Hospital Completed No outcome recorded
Phase 2 NCT00509067 Background Nov 2007 → Mar 2011 schizophrenia Georgetown University Completed No outcome recorded
Phase 2 NCT00490542 Comparator Dec 2006 → Aug 2009 bipolar depression Tufts Medical Center Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00340379 Comparator Apr 2003 → Aug 2005 mood disorder Duke University Completed No outcome recorded
Phase 37 trials
Phase 3 NCT01117220 Comparator Jun 2010 → Apr 2011 bipolar disorder Viatris Inc. Withdrawn No outcome recorded
Phase 3 NCT00257192 Comparator Apr 2006 → Mar 2009 schizophrenia Viatris Inc. Terminated No outcome recorded
Phase 3 NCT00282464 Comparator Feb 2006 → Mar 2008 bipolar I disorder Viatris Inc. Completed No outcome recorded
Phase 3 NCT00288353 Comparator Jan 2006 → Dec 2008 bipolar disorder, schizoaffective disorder, schizophrenia Northwestern University Terminated No outcome recorded
Phase 3 NCT00254202 Comparator Nov 2005 → Sep 2006 schizophrenia Vanda Pharmaceuticals Completed No outcome recorded
Phase 418 trials
Phase 4 NCT05741502 Comparator Aug 2023 → Jan 2026 schizophrenia Ohio State University Terminated No outcome recorded
Phase 4 NCT02282085 Comparator Dec 2014 → Dec 2017 schizophrenia Matt Byerly Unknown No outcome recorded
Phase 4 NCT02237417 Comparator Sep 2014 → Nov 2018 schizophrenia University of Utah Completed No outcome recorded
Phase 4 NCT02040883 Background Feb → Dec 2014 schizophrenia Qingyun Yin Unknown No outcome recorded
Phase 4 NCT01844700 Comparator Jul 2013 → Apr 2014 obesity due to melanocortin 4 receptor deficiency Northwell Health Terminated No outcome recorded
Phase not applicable7 trials
NCT02192723 Comparator Jun 2012 → Jun 2014 schizophrenia Beijing HuiLongGuan Hospital Completed No outcome recorded
NCT01485692 Comparator Feb 2009 → Mar 2011 University of Sao Paulo Completed No outcome recorded
NCT00910988 Comparator Feb 2009 → Jun 2012 hyperglycemia, hyperlipidemia Washington University School of Medicine Completed No outcome recorded
NCT00538642 Comparator Aug 2007 → Apr 2011 bipolar disorder, schizoaffective disorder, schizophrenia The University of Texas Health Science Center at San Antonio Completed No outcome recorded
NCT00288366 Comparator Jan 2006 → Dec 2008 bipolar disorder, schizoaffective disorder, schizophrenia Northwestern University Completed No outcome recorded

Evidence & citations 25 cited values

Every value below carries the sentence it was read from. 127 sources stand behind the page.

FieldValueCited text
Known as Ziprasidone “Drugs: Aripiprazole, Olanzapine, Zuclopenthixol, Clotiapine, Flupentixol, Risperidone, Sulpiride, Trifluoperazine, Haloperidol, Quetiapine, Paliperidone, Chlorpromazine,...” NCT01765829
124

“There has been evidence that ziprasidone is efficacious in decreasing the magnitude of both positive and negative symptoms of schizophrenia, and also effective in the treatment...” NCT00159757

“Thirty patients will receive ziprasidone treatment, in progressively increasing doses, starting from 40 mg per day, and the other 30 patients will receive placebo” NCT00197951

“Second generation antipsychotics included risperidone, paliperidone, iloperidone, quetiapine, olanzapine, ziprasidone, asenapine and lurasidone.” NCT03319953

“Including Olanzapine, Risperidone, Paliperidone, Quetiapine, Aripiprazole, Ziprasidone, Lurasidone, Cariprazine, and all Typical antipsychotics” NCT05741502

“Participants who are switched to ziprasidone will take a max daily dose of 200 mg, flexibly dosed based on symptoms and adverse effects.” NCT00338949

“Oral antipsychotic agents, olanzapine, quetiapine, ziprasidone, aripiprazole in doses approved in the US for bipolar disorder” NCT00177164

“Quetiapine 25-800 mg; ziprasidone 80-160 mg; olanzapine 5-20mg; risperidone 2-8 mg; aripiprazole 15-30 mg” NCT01016145

Ziprasidone is an atypical antipsychotic recommended to be administered twice daily.” PMID 23417515 Feb 2013

“switched to Zoladine capsules (ziprasidone hydrochloride capsules)” NCT04975035

Ziprasidone(according to response, and tolerance)40-160mg” NCT01000402

“or ziprasidone) throughout the study.” NCT03565068

ziprasidone HCI(Geodon®)” NCT02237417

“Geodon (Ziprasidone)” NCT00141271

“or Ziprasidone.” NCT02181803

NCT00932529

NCT02374567

NCT04076371

NCT01893229

NCT00555997

NCT02282085

NCT02075047

NCT02040883

NCT00835107

NCT00297960

NCT00635700

NCT02526030

NCT00406315

NCT00139737

NCT04446234

NCT02307396

NCT00215150

NCT02305823

NCT00159770

NCT00821444

NCT00048802

NCT00340379

NCT02650102

NCT00181922

NCT00633399

NCT00421954

NCT00472641

NCT00208559

NCT00458211

NCT02935998

NCT01485692

NCT00096863

NCT01168674

NCT00329108

NCT00257192

NCT00374543

NCT00034801

NCT01844700

NCT00199940

NCT00282464

NCT00748566

NCT03781115

NCT00650611

NCT00224315

NCT02534363

NCT01117220

NCT00403546

NCT00351000

NCT01185743

NCT00515723

NCT00229385

NCT00145444

NCT03011645

NCT00650429

NCT01157559

NCT00239109

NCT00148564

NCT00143351

NCT01006551

NCT02192723

NCT00395031

NCT00174447

NCT00205725

NCT00237666

NCT00265330

NCT00280566

NCT00723606

NCT01293825

NCT00490542

NCT00622739

NCT00044655

NCT00254202

NCT00014001

NCT00312494

NCT00635921

NCT04587115

NCT01211522

NCT01124877

NCT00136994

NCT00418171

NCT00208208

NCT00483548

NCT00634348

NCT00137020

NCT00347425

NCT00509067

NCT00538642

NCT00288353

NCT00649844

NCT01113541

NCT00225498

NCT00288366

NCT00644800

NCT00786318

NCT01198353

NCT01172652

NCT03557931

NCT00645229

NCT03837860

NCT03768726

NCT00330863

NCT00645320

NCT00806234

NCT00910988

NCT00265382

NCT00645372

NCT01714011

NCT00649064

NCT00645515

NCT00257166

Known as CP-88, 059-27 ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as CP-88,059-1 ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as CP-88059 ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as Geodon “Patients will be switched from their current antipsychotic medication to aripiprazole (Abilify) or ziprasidone (Geodon) (unless clinically contraindicated) for comparison with...” NCT00288366
13

“The purpose of this study is to evaluate the antidepressant effectiveness of Geodon for the treatment of patients diagnosed with Bipolar II disorder who are currently...” NCT00237666

“This is a 6-week trial that evaluates the efficacy and safety of Geodon (ziprasidone) in outpatient subjects ages 18 and older with Bipolar Disorder type I, depressed.” NCT00282464

“This open-label study will assess the medication Geodon® (Ziprasidone) in pediatric patients” NCT00421954

“Olanzapine (Zyprexa), Quetiapine (Seroquel), Ziprasidone (Geodon), Aripiprazole (Ablify)” NCT00177164

Geodon (Ziprasidone) for Posttraumatic Stress Disorder” NCT00208208

“ziprasidone HCI(Geodon®)” NCT02237417

“ziprasidone (Geodon)” NCT00288353

“ziprasidone (Geodon)” NCT00490542

“ziprasidone (Geodon)” NCT00181922

“ziprasidone/GeodonNCT00910988

“Ziprasidone/GeodonNCT00472641

Geodon, Zeldox” NCT00650429

NCT00141271

Known as NSC-760351 ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as Zeldox “Geodon, ZeldoxNCT00650429
Known as ZIP “5. 220 begin double-blind treatment with ziprasidone (ZIP)” NCT00014001
Known as Zipradon ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as Ziprasidona ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as ziprasidone HCI ziprasidone HCI(Geodon®)” NCT02237417
Known as ziprasidone hydrochloride “switched to Zoladine capsules (ziprasidone hydrochloride capsules)” NCT04975035
3

“Drug: ziprasidone hydrochlorideNCT00329108

“Drug: ziprasidone hydrochlorideNCT00835107

NCT00676429

Known as Ziprasidone hydrochloride hydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as Ziprasidone hydrochloride monohydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as Ziprasidone mesilate ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as Ziprasidone mesilate trihydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as ZIPRASIDONE MESYLATE ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as Ziprasidone mesylate anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL708
Known as Zoladine “switched to Zoladine capsules (ziprasidone hydrochloride capsules)” NCT04975035
Action Inhibit “Serotonin 2a (5-HT2a) receptor antagonist” CHEMBL708
2

“both D2 and 5HT2 antagonistic effects” NCT00181922

“Dopamine D2 receptor antagonist” CHEMBL708

Modality Small molecule CHEMBL708
Route Oral oral liquid formulations of haloperidol versus ziprasidone versus placebo” NCT00096863
Target DRD2 “Dopamine D2 receptor antagonist” CHEMBL708
Target HTR2A “Serotonin 2a (5-HT2a) receptor antagonist” CHEMBL708
Target HTR2C “antagonist (ziprasidone) to reduce cortisol response to mental and metabolic stress in men carrying the rs6318 C allele and women in the rs6318 CC genotype of 5HTR2C.” NCT03011645