Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared To Injectables: Evaluating Efficacy

Phase 4 Completed 357 enrolled Northwell Health National Institute of Mental Health (NIMH) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

This study is designed to find out whether taking antipsychotic medication once every two weeks by injection compared to taking daily oral medication will help people with schizophrenia maintain better control of their symptoms.

Timeline

Start: 2006-05
Primary completion: 2011-01
Completion: 2011-01

Publications

Results Buckley PF, Schooler NR, Goff DC, Hsiao J, Kopelowicz A, Lauriello J, Manschreck T, Mendelowitz AJ, Miller del D, Severe JB, Wilson DR, Ames D, Bustillo J, Mintz J, Kane JM; PROACTIVE Study. Comparison of SGA oral medications and a long-acting injectable SGA: the PROACTIVE study. Schizophr Bull. 2015 Mar;41(2):449-59. doi: 10.1093/schbul/sbu067. Epub 2014 May 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Aripiprazole	Other / unclassified	20 mg	Oral
Comparator	Olanzapine	Small molecule	15 mg	Oral
Comparator	Paliperidone	Unknown	6 mg	Oral
Comparator	Quetiapine	Small molecule	600 mg	Oral
Comparator	Risperidone	Other / unclassified	4 mg	Oral
Subject	Risperidone microspheres	Unknown	12.5 mg	Other
Subject	Risperidone microspheres	Unknown	75 mg	Other
Comparator	Ziprasidone	Small molecule	120 mg	Oral

Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared To Injectables: Evaluating Efficacy

Summary

Timeline

Publications

Drugs

Indications