drugset / Trial / NCT00159133
Prodrome-Based Early Intervention With Antipsychotics vs. Benzodiazepines in First-Episode Schizophrenia
Phase 4
Completed
71 enrolled
Heinrich-Heine University, Duesseldorf
German Federal Ministry of Education and Research · collabGerman Research Network On Schizophrenia · collabHumboldt-Universität zu Berlin · collabJanssen-Cilag Ltd. · collabLudwig-Maximilians - University of Munich · collabMainz University · collabMartin-Luther-Universität Halle-Wittenberg · collabRWTH Aachen University · collabUniversity Hospital Tuebingen · collabUniversity of Bonn · collabUniversity of Cologne · collabUniversity of Göttingen · collabUniversity of Jena · collabUniversity of Mannheim · collabUniversity of Wuerzburg · collabUniversität Duisburg-Essen · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Prodrome based early intervention with an antipsychotic drug vs. benzodiazepine was applied in patients with first episode schizophrenia after one year neuroleptic maintenance treatment. Two groups of patients were followed over a period of 1 year: one further on under maintenance neuroleptic treatment, the other one after stepwise drug discontinuation.
Timeline
- Start
- 2001-11
- Primary completion
- 2006-06
- Completion
- 2006-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Haloperidol | Other / unclassified | — | — |
| Subject | Lorazepam | Small molecule | 3 mg | — |
| Subject | Risperidone | Other / unclassified | — | — |