drugset / Trial / NCT01870024

Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus

NCT01870024

Phase 3 Completed 434 enrolled Assistance Publique - Hôpitaux de Paris
RandomizedParallel-groupDouble-blindTreatment

Summary

The main purpose of this study is to know on one hand if lorazepam is more (effective) than clonazepam and on the other hand if lorazepam is also effective as the association clonazepam + fosphenytoin in out-of-hospital treatment of the generalized convulsive status epilepticus in adult patients.

Timeline

Start
2013-06-26
Primary completion
2018-02-23
Completion
2018-02-23

Drugs

EvaluationDrugModalityDoseRoute
Comparator Clonazepam Small molecule 0.015 mg/kg Intravenous
Comparator Fosphenytoin Small molecule 20 mg/kg Intravenous
Comparator Lorazepam Small molecule 0.1 mg/kg Intravenous

Indications