drugset / Trial / NCT06549426
Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
Recruiting
150 enrolled
University of Twente
Belgium Health Care Knowledge Centre · collabErasme University Hospital · collabZonMw: The Netherlands Organisation for Health Research and Development · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest. The main questions the trial aims to answer are: * Does ESE treatment improve outcome? * What is the impact of ESE treatment on healthcare costs? Participants in the the intervention group will receive standard care completed with anti-seizure treatment. The control group will receive standard care without anti-seizure treatment.
Timeline
- Start
- 2025-04-10
- Primary completion
- 2029-12
- Completion
- 2030-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Diazepam | Small molecule | — | Other |
| Subject | Ketamine | Small molecule | — | Other |
| Subject | Lacosamide | Other / unclassified | — | Other |
| Subject | Levetiracetam | Other / unclassified | — | Other |
| Subject | Lorazepam | Small molecule | — | Other |
| Subject | Midazolam | Small molecule | — | Other |
| Subject | Propofol | Small molecule | — | Other |
| Subject | Valproate | Small molecule | — | Other |