drugset / Trial / NCT00429702
Diphenhydramine, Lorazepam, and Dexamethasone in Treating Nausea and Vomiting Caused By Chemotherapy
RandomizedParallel-groupTriple-blindSupportive care
Summary
RATIONALE: Diphenhydramine, lorazepam, and dexamethasone may help lessen or prevent nausea and vomiting in patients treated with chemotherapy. It is not yet known whether diphenhydramine, lorazepam, and dexamethasone are more effective than standard therapy in treating nausea and vomiting caused by chemotherapy. PURPOSE: This randomized phase II trial is studying diphenhydramine, lorazepam, and dexamethasone to see how well they work compared with standard therapy in treating nausea and vomiting caused by chemotherapy in young patients with newly diagnosed cancer.
Timeline
- Start
- 2007-10
- Primary completion
- 2009-08
- Completion
- 2009-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexamethasone | Small molecule | — | Intravenous |
| Subject | Diphenhydramine | Unknown | — | Intravenous |
| Subject | Lorazepam | Small molecule | — | Intravenous |
| Background | Ondansetron | Other / unclassified | — | Intravenous |