Assessment of Peripheral GABA Receptors for Local Pain Relief

Unknown 90 enrolled Aalborg University

RandomizedParallel-groupDouble-blindBasic science

Summary

The effect of peripheral GABAA receptor activation on pain and sensitivity in healthy human subjects has never been investigated. However, as earlier studies suggest that activation of peripheral GABAA receptors is anti-nociceptive in rats, it is important to determine if these findings can be translated into human subjects to determine if peripheral GABAA receptors are a viable target for future analgesic drug development.

Timeline

Start: 2016-10
Primary completion: 2018-12
Completion: 2019-12

Publications

Results Zhang Y, Wang K, Arendt-Nielsen L, Cairns BE. gamma-Aminobutyric acid (GABA) oral rinse reduces capsaicin-induced burning mouth pain sensation: An experimental quantitative sensory testing study in healthy subjects. Eur J Pain. 2018 Feb;22(2):393-401. doi: 10.1002/ejp.1128. Epub 2017 Oct 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Gamma-Aminobutyric Acid	Small molecule	50 mmol	Oral
Subject	Gamma-Aminobutyric Acid	Small molecule	500 mmol	Oral
Subject	Lidocaine	Other / unclassified	1 %	Oral
Subject	Lorazepam	Small molecule	—	Intramuscular

Indications

No indication recorded.