Comparing the Effectiveness of Oral Versus Intravenous Pain Medicine for Suction Curettage (D&C)

Summary

The main objective of this study is to determine the equivalency of oral conscious sedation and intravenous conscious sedation for first trimester surgical abortion. We hypothesize that oral conscious sedation will be equivalent to intravenous conscious sedation for pain control. Additional objectives include describing subject satisfaction with each method of pain control and characteristics of each method such as side effect profile, recovery room time, and postoperative pain.

Timeline

Start

2006-06

Primary completion

2007-07

Completion

2007-07

Outcome

Missed primary endpoint

Stopped (Enrollment): “DSMB review at 50% recruitment, further recruitment unlikely to change result”

paper CONCLUSION: Oral sedation, as studied, is not equivalent to intravenous sedation for pain control during first-trimester surgical abortion. PMID 19155895 ↗

Publications

• Allen RH, Fitzmaurice G, Lifford KL, Lasic M, Goldberg AB. Oral compared with intravenous sedation for first-trimester surgical abortion: a randomized controlled trial. Obstet Gynecol. 2009 Feb;113(2 Pt 1):276-83. doi: 10.1097/AOG.0b013e3181938758.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fentanyl	Other / unclassified	100 ug	Intravenous
Subject	Lorazepam	Small molecule	1 mg	Other
Subject	Midazolam	Small molecule	2 mg	Intravenous
Subject	Oxycodone	Other / unclassified	10 mg	Oral

Indications

No indication recorded.