Drugs / Methadone
Methadone
also known as
methadone hydrochloride · Dolophine · Methadone HCl · MET · Methadose · Methadose/ Metadol D/Compounded methadone
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | METHADONE HYDROCHLORIDE | — | 1947-08-13 | fda.gov ↗ |
Trials 132 · started per year
today
US approved 1947
1
1
1
2
2
2
1
1
2
3
4
2
2
1
11
5
8
5
7
5
3
5
5
1
6
2
2
2
8
10
13
8
1
19461947194819491950195119521953195419551956195719581959196019611962196319641965196619671968196919701971197219731974197519761977197819791980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028202920302031
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 05 trials | ||||||
| Phase 0 | NCT06810336 | Mar 2025 → Sep 2027 expected | brain injury, brain neoplasm | University of Virginia | Recruiting | No outcome recorded |
| Phase 0 | NCT06387303 | Aug 2024 → May 2026 overdue | — | University of Virginia | Recruiting | No outcome recorded |
| Phase 0 | NCT05789173 | Oct 2023 → Aug 2026 overdue | — | Indiana University | Recruiting | No outcome recorded |
| Phase 0 | NCT04027166 | Jul 2019 → Mar 2021 | — | Yale University | Completed | No outcome recorded |
| Phase 0 | NCT03525509 | Jun 2018 → Aug 2019 | — | simon.haroutounian | Completed | No outcome recorded |
| Phase 125 trials | ||||||
| Phase 1 | NCT07595263 | Aug 2026 → Jan 2027 expected | — | Merck Sharp & Dohme LLC | Recruiting | No outcome recorded |
| Phase 1 | NCT07528508 | May → Aug 2026 overdue | — | Merck Sharp & Dohme LLC | Recruiting | No outcome recorded |
| Phase 1 | NCT06877858 | Sep 2025 → Mar 2027 expected | substance-related disorder | University of Pennsylvania | Recruiting | No outcome recorded |
| Phase 1 | NCT07314346 | Jan 2025 → Aug 2026 overdue | — | Atea Pharmaceuticals, Inc. | Recruiting | No outcome recorded |
| Phase 1 | NCT02666001 | Jan → Jun 2016 | HIV infectious disease | ViiV Healthcare | Completed | No outcome recorded |
| Phase 1 | NCT02715700 | Sep 2015 → Jun 2016 | HIV infectious disease | Merck Sharp & Dohme LLC | Completed | No outcome recorded |
| Phase 1 | NCT02531906 | Apr 2015 → Jun 2018 | head and neck squamous cell carcinoma, stomatitis | Roswell Park Cancer Institute | Completed | No outcome recorded |
| Phase 1 | NCT01677650 | Mar 2014 → Jan 2015 | scoliosis | Northwestern University | Withdrawn | No outcome recorded |
| Phase 1 | NCT02045693 | Feb → Apr 2014 | hepatitis C virus infection | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 1 | NCT01582425 | Apr → Jun 2012 | — | Astellas Pharma Global Development, Inc. | Completed | No outcome recorded |
| Phase 1 | NCT01467518 | Dec 2011 → Feb 2012 | HIV infectious disease | ViiV Healthcare | Completed | No outcome recorded |
| Phase 1 | NCT01396005 | Sep → Dec 2011 | hepatitis C virus infection | Merck Sharp & Dohme LLC | Completed | No outcome recorded |
| Phase 1 | NCT01389544 | Jun → Jul 2011 | — | Hoffmann-La Roche | Completed | No outcome recorded |
| Phase 1 | NCT01210404 | Feb → May 2011 | chronic hepatitis C virus infection | Pfizer | Completed | No outcome recorded |
| Phase 1 | NCT00933283 | Jul → Nov 2009 | — | Tibotec BVBA | Completed | No outcome recorded |
| Phase 1 | NCT00715988 | Oct 2007 → Sep 2012 | — | University of Utah | Completed | No outcome recorded |
| Phase 1 | NCT00504413 | Jul 2007 → Jan 2011 | substance-related disorder | University of Washington | Unknown | No outcome recorded |
| Phase 1 | NCT00481182 | Feb 2005 → ? | — | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 1 | NCT02245451 | Jan → Feb 2005 | — | Boehringer Ingelheim | Completed | No outcome recorded |
| Phase 1 | NCT00292110 | Feb 2004 → Aug 2013 | cocaine abuse, opiate dependence | National Institute on Drug Abuse (NIDA) | Completed | No outcome recorded |
| Phase 1 | NCT00125294 | Sep 2003 → Jun 2006 | cancer | AHS Cancer Control Alberta | Completed | No outcome recorded |
| Phase 1 | NCT00292123 | Jun 1999 → Jun 2006 | cocaine abuse, opiate dependence | National Institute on Drug Abuse (NIDA) | Completed | No outcome recorded |
| Phase 1 | NCT00000906 | ? → Sep 2000 | HIV infectious disease | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | No outcome recorded |
| Phase 1 | NCT00000800 | ? → Oct 1998 | HIV infectious disease | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | No outcome recorded |
| Phase 1 | NCT00000788 | ? → Jun 1994 | HIV infectious disease, candidiasis | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | No outcome recorded |
| Phase 1/23 trials | ||||||
| Phase 1/2 | NCT05425420 | Aug 2023 → Jan 2024 | — | Kanecia Obie Zimmerman | Completed | No outcome recorded |
| Phase 1/2 | NCT01327079 | Dec 2010 → Dec 2017 | pulmonary immaturity | John van den Anker | Completed | No outcome recorded |
| Phase 1/2 | NCT01094522 | Mar 2010 → Jun 2012 | — | Stanford University | Completed | No outcome recorded |
| Phase 216 trials · 3 missed | ||||||
| Phase 2 | NCT06536517 | Mar 2025 → Dec 2026 expected | leiomyoma | Johns Hopkins University | Recruiting | No outcome recorded |
| Phase 2 | NCT04480554 | Jan 2023 → Jun 2025 | HIV infectious disease, opiate dependence | University of Pennsylvania | Terminated | No outcome recorded Stop: Business |
| Phase 2 | NCT03605901 | Mar 2019 → May 2025 | neuropathy, painful | University of Florida | Terminated | Missed primary |
| Phase 2 | NCT03908944 | Jan 2019 → Jan 2021 | — | Steven Edelstein | Withdrawn | No outcome recorded |
| Phase 2 | NCT03134703 | Feb 2017 → Mar 2019 | neonatal abstinence syndrome | Johns Hopkins All Children's Hospital | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT02774499 | Apr → Aug 2016 | — | University of Saskatchewan | Completed | Missed primary |
| Phase 2 | NCT01795495 | Sep 2013 → Aug 2016 | idiopathic scoliosis | Nationwide Children's Hospital | Completed | Mixed |
| Phase 2 | NCT01429181 | Jan 2012 → Sep 2014 | diabetic polyneuropathy | MetaPharm, Inc. | Completed | No outcome recorded |
| Phase 2 | NCT00863057 | May 2009 → Dec 2010 | HIV infectious disease, peripheral neuropathy | National Institute of Allergy and Infectious Diseases (NIAID) | Terminated | Missed primary Stop: Enrollment |
| Phase 2 | NCT00723918 | Apr 2009 → Jan 2010 | polyneuropathy | Washington University School of Medicine | Withdrawn | No outcome recorded |
| Phase 2 | NCT00351715 | Jul → Sep 2008 | cancer | AHS Cancer Control Alberta | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT00351637 | Dec 2006 → Sep 2008 | cancer | Alberta Health services | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT00142727 | Jan 2004 → Feb 2006 | substance-related disorder | National Institute on Drug Abuse (NIDA) | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT00000328 | Jul → Aug 1997 | heroin dependence | University of Colorado, Denver | Withdrawn | No outcome recorded |
| Phase 2 | NCT00000200 | Jan 1997 → Jan 1998 | cocaine abuse | National Institute on Drug Abuse (NIDA) | Completed | No outcome recorded |
| Phase 2 | NCT00344812 | Jan 1996 → Jun 1998 | opiate dependence | Johns Hopkins University | Completed | No outcome recorded |
| Phase 2/34 trials | ||||||
| Phase 2/3 | NCT05786599 | Mar 2025 → Mar 2026 overdue | chemotherapy-induced neuropathy | University of British Columbia | Recruiting | No outcome recorded |
| Phase 2/3 | NCT05693675 | Oct 2023 → Jul 2024 | — | The University of Texas Health Science Center, Houston | Withdrawn | No outcome recorded Stop: Enrollment |
| Phase 2/3 | NCT01082679 | Jun 2009 → Mar 2011 | opiate dependence | University of Wisconsin, Madison | Completed | No outcome recorded |
| Phase 2/3 | NCT00525967 | Feb 2006 → Oct 2007 | cancer | Faculdade de Medicina do ABC | Unknown | No outcome recorded |
| Phase 322 trials · 2 met primary | ||||||
| Phase 3 | NCT06940570 | Jan 2028 → Aug 2029 | aplastic anemia, bone marrow failure syndrome, leukemia, severe combined immunodeficiency | University of Texas Southwestern Medical Center | Suspended | No outcome recorded Stop: Business |
| Phase 3 | NCT07565870 | Jul → Dec 2026 expected | — | Alexandre P. Joosten | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT06626035 | Dec 2025 → Jan 2029 expected | — | Senthil Sadhasivam | Recruiting | No outcome recorded |
| Phase 3 | NCT06626503 | Oct 2025 → Jan 2029 expected | idiopathic scoliosis | Senthil Sadhasivam | Recruiting | No outcome recorded |
| Phase 3 | NCT06351215 | May → Dec 2025 overdue | — | Keck School of Medicine of USC | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT06593665 | Sep 2024 → Dec 2026 expected | testicular cancer | Indiana University | Recruiting | No outcome recorded |
| Phase 3 | NCT06728371 | Mar → Dec 2024 overdue | neuropathy, painful | Chinese University of Hong Kong | Recruiting | No outcome recorded |
| Phase 3 | NCT05913284 | Jan 2024 → Feb 2026 overdue | chronic pain syndrome, neuropathy, painful | Chinese University of Hong Kong | Active not recruiting | No outcome recorded |
| Phase 3 | NCT05831345 | Feb 2023 → Dec 2025 overdue | — | Brugmann University Hospital | Recruiting | No outcome recorded |
| Phase 3 | NCT05325164 | Sep 2022 → Aug 2023 | adenocarcinoma | Ottawa Hospital Research Institute | Withdrawn | No outcome recorded |
| Phase 3 | NCT04908345 | May 2021 → Jan 2022 | chronic renal failure syndrome | University of Sao Paulo General Hospital | Unknown | No outcome recorded |
| Phase 3 | NCT04680286 | Nov 2020 → Jan 2024 | — | University of Aarhus | Terminated | No outcome recorded Stop: Enrollment |
| Phase 3 | NCT05235191 | Sep 2019 → Jan 2023 | neuropathy, painful | University of Sao Paulo | Completed | No outcome recorded |
| Phase 3 | NCT02558010 | Feb 2016 → Jan 2022 | scoliosis | Medical College of Wisconsin | Completed | Met primary |
| Phase 3 | NCT02687347 | Feb 2016 → Feb 2018 | neurological pain disorder | McGill University Health Centre/Research Institute of the McGill University Health Centre | Unknown | No outcome recorded |
| Phase 3 | NCT01793480 | Jan 2012 → May 2014 | — | RECORDATI GROUP | Completed | No outcome recorded |
| Phase 3 | NCT01205256 | Mar 2009 → Apr 2010 | scoliosis | University of Virginia | Completed | No outcome recorded |
| Phase 3 | NCT00657397 | Jan 2009 → Dec 2011 | hepatitis C virus infection, substance dependence | French National Agency for Research on AIDS and Viral Hepatitis | Completed | Met primary |
| Phase 3 | NCT00356083 | Jan 2004 → Mar 2005 | chronic pain syndrome | Norwegian University of Science and Technology | Completed | No outcome recorded |
| Phase 3 | NCT00378079 | Sep 2003 → Jan 2008 | heroin dependence | Friends Research Institute, Inc. | Completed | No outcome recorded |
| Phase 3 | NCT01752699 | Jan 1998 → Feb 2013 | postherpetic neuralgia | University of Sao Paulo | Completed | No outcome recorded |
| Phase 3 | NCT00000311 | Feb 1995 → Feb 1999 | substance-related disorder | Yale University | Completed | No outcome recorded |
| Phase 441 trials · 3 met primary | ||||||
| Phase 4 | NCT07857655 | Sep 2026 → Jul 2029 expected | hypopharyngeal carcinoma, laryngeal carcinoma, oral cavity carcinoma, oropharyngeal carcinoma | OHSU Knight Cancer Institute | Recruiting | No outcome recorded |
| Phase 4 | NCT07517679 | Jun 2026 → Apr 2027 expected | — | Brandon Knopp | Recruiting | No outcome recorded |
| Phase 4 | NCT07485803 | Jun 2026 → Apr 2028 expected | — | AdventHealth | Recruiting | No outcome recorded |
| Phase 4 | NCT07546396 | May 2026 → Mar 2027 expected | substance-related disorder | Pouya Azar | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07365800 | Apr → Dec 2026 expected | upper thoracic spina bifida aperta | University of Missouri-Columbia | Enrolling by invitation | No outcome recorded |
| Phase 4 | NCT06868589 | Jun 2025 → Jul 2026 overdue | — | Lahey Clinic | Active not recruiting | No outcome recorded |
| Phase 4 | NCT06720415 | Apr → Jul 2025 | — | Mayo Clinic | Completed | No outcome recorded |
| Phase 4 | NCT06843174 | Feb 2025 → Jul 2026 overdue | — | Unity Health Toronto | Recruiting | No outcome recorded |
| Phase 4 | NCT06826742 | Feb → Sep 2025 | — | Mayo Clinic | Completed | No outcome recorded |
| Phase 4 | NCT06784999 | Jan 2025 → Nov 2027 expected | — | Indiana University | Recruiting | No outcome recorded |
| Phase 4 | NCT06525740 | Sep 2024 → Sep 2029 expected | female reproductive organ cancer | Mayo Clinic | Recruiting | No outcome recorded |
| Phase 4 | NCT06323824 | Jun 2024 → Dec 2028 expected | substance-related disorder | Yale University | Recruiting | No outcome recorded |
| Phase 4 | NCT06691633 | Feb → Sep 2024 | osteoarthritis, knee | University of Louisville | Completed | No outcome recorded |
| Phase 4 | NCT06110546 | Feb 2024 | — | The University of Texas Health Science Center, Houston | Terminated | No outcome recorded Stop: Enrollment |
| Phase 4 | NCT05905367 | Jan 2024 → Dec 2025 | substance-related disorder | Pouya Azar | Completed | No outcome recorded |
| Phase 4 | NCT06086171 | Nov 2023 → Oct 2024 | — | University of Southern Denmark | Completed | No outcome recorded |
| Phase 4 | NCT05845359 | Sep 2023 → Feb 2024 | — | Montefiore Medical Center | Withdrawn | No outcome recorded |
| Phase 4 | NCT05581901 | Jan → Mar 2023 | — | University of Southern Denmark | Completed | No outcome recorded |
| Phase 4 | NCT05445856 | Nov 2022 → Jan 2024 | — | University of Aarhus | Unknown | Met primary |
| Phase 4 | NCT04764825 | Feb 2021 → Mar 2024 | spinal stenosis, spondylolisthesis | University of Aarhus | Terminated | No outcome recorded |
| Phase 4 | NCT04526236 | Sep 2019 → Jul 2022 | acute opioid poisoning, neuropathy, painful, substance-related disorder | Pontificia Universidad Catolica de Chile | Completed | No outcome recorded |
| Phase 4 | NCT03033732 | Oct 2017 → Mar 2020 | substance-related disorder | Didier Jutras Aswad | Completed | Met primary |
| Phase 4 | NCT02989597 | Jul 2017 → Nov 2020 | — | Montefiore Medical Center | Terminated | No outcome recorded |
| Phase 4 | NCT02958566 | Jan → Dec 2017 | colon carcinoma, constipation disorder, diverticulitis of colon, paralytic ileus +1 | University of Illinois College of Medicine at Peoria | Unknown | No outcome recorded |
| Phase 4 | NCT02775474 | Jun 2016 → Jan 2017 | chronic pain syndrome, neuropathy, painful | University of Sao Paulo General Hospital | Completed | No outcome recorded |
| Phase 4 | NCT04254731 | May 2015 → Jun 2018 | cardiac rhythm disease | Oslo University Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT02107339 | Mar 2014 → Jul 2016 | — | Endeavor Health | Completed | No outcome recorded |
| Phase 4 | NCT02025855 | Jan 2014 → Oct 2017 | delirium, drug-induced mental disorder, substance withdrawal syndrome | Henry Ford Health System | Terminated | No outcome recorded |
| Phase 4 | NCT05368675 | Dec 2013 → Aug 2017 | HIV infectious disease, opiate dependence | University of Pennsylvania | Completed | No outcome recorded |
| Phase 4 | NCT02252432 | Feb 2013 → Jan 2023 | — | Cedars-Sinai Medical Center | Terminated | No outcome recorded Stop: Enrollment |
| Phase 4 | NCT01205516 | Jan 2013 → Dec 2017 | neuropathy, painful | Nova Scotia Health Authority | Terminated | No outcome recorded Stop: Enrollment |
| Phase 4 | NCT03529032 | Mar 2012 → Jul 2013 | neuropathy, painful | Kantonsspital Baden | Completed | No outcome recorded |
| Phase 4 | NCT01546948 | Aug 2011 → Jun 2018 | — | Endeavor Health | Completed | No outcome recorded |
| Phase 4 | NCT02335398 | Jul 2011 → Dec 2013 | chronic pain syndrome | Mahidol University | Completed | No outcome recorded |
| Phase 4 | NCT01317589 | May 2011 → Jul 2015 | head and neck cancer | Maastricht University Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT01542645 | Sep 2010 → Nov 2013 | chronic pain syndrome, neuropathy, painful | Endeavor Health | Completed | No outcome recorded |
| Phase 4 | NCT02396979 | Jan 2010 → Dec 2014 | AIDS, opiate dependence | Yale University | Completed | No outcome recorded |
| Phase 4 | NCT00921843 | May 2009 → May 2011 | — | Washington University School of Medicine | Completed | No outcome recorded |
| Phase 4 | NCT00892606 | Jan 2009 → Dec 2013 | — | University of Louisville | Completed | Met primary |
| Phase 4 | NCT00310934 | Aug 2005 → Mar 2006 | heroin dependence | Karolinska University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT00279565 | Aug 2005 → Feb 2007 | chronic hepatitis C virus infection | Indivior Inc. | Terminated | No outcome recorded |
| Phase not applicable16 trials · 2 met primary · 1 missed | ||||||
| — | NCT06240390 | May → Aug 2024 | neuropathy, painful | Universidad Europea de Canarias | Withdrawn | No outcome recorded Stop: Enrollment |
| — | NCT04475029 | Jul 2020 → Aug 2023 | nervous system disorder, neuropathy, painful, urinary bladder cancer | University of Aarhus | Completed | No outcome recorded |
| — | NCT03908060 | May 2019 → Jul 2022 | — | University of Aarhus | Unknown | Met primary |
| — | NCT03098407 | Apr 2017 → Oct 2019 | opiate dependence, pregnancy disorder | University of Pittsburgh | Completed | No outcome recorded |
| — | NCT02334215 | Dec 2014 → Mar 2019 | substance-related disorder | Friends Research Institute, Inc. | Completed | Mixed |
| — | NCT01160432 | May → Jul 2013 | opiate dependence | Kuopio University Hospital | Withdrawn | No outcome recorded |
| — | NCT01990573 | Apr 2013 → Jun 2018 | — | Washington University School of Medicine | Completed | Mixed |
| — | NCT01833715 | Mar → Aug 2013 | — | Universidad de Valparaiso | Completed | No outcome recorded |
| — | NCT01648283 | Nov 2012 → Mar 2015 | — | Washington University School of Medicine | Completed | No outcome recorded |
| — | NCT01430182 | Sep 2011 → Jul 2014 | — | Baylor College of Medicine | Terminated | Missed primary Stop: Enrollment |
| — | NCT00999440 | Jan → Dec 2010 | chronic pain syndrome | Tel-Aviv Sourasky Medical Center | Unknown | No outcome recorded |
| — | NCT01594047 | Dec 2009 → Jun 2012 | — | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | Completed | Met primary |
| — | NCT01580163 | Sep 2009 → Aug 2013 | heroin dependence | Shanghai Mental Health Center | Completed | No outcome recorded |
| — | NCT00726830 | Mar 2009 → Sep 2010 | cancer of unknown primary site, central nervous system neoplasm, leukemia, lymphoproliferative syndrome +5 | M.D. Anderson Cancer Center | Terminated | No outcome recorded Stop: Enrollment |
| — | NCT00006448 | Aug 1996 → Jul 2001 | spinal cord injury | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Completed | No outcome recorded |
| — | NCT00001008 | ? → Mar 1991 | HIV infectious disease | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | No outcome recorded |
| Comparator or background therapy77 trials | ||||||
| Phase 0 | NCT04308694 Background | Aug 2020 → Jan 2021 | substance-related disorder | Friends Research Institute, Inc. | Completed | No outcome recorded |
| Phase 1 | NCT05251376 Background | Feb → Dec 2022 | opiate dependence | Lyndra Inc. | Withdrawn | No outcome recorded Stop: Business |
| Phase 1 | NCT04112550 Comparator | Feb 2020 → Dec 2021 | intervertebral disk degenerative disorder, spondylolisthesis | The Methodist Hospital Research Institute | Unknown | No outcome recorded |
| Phase 1 | NCT02033707 Background | Apr 2014 → Feb 2019 | — | Johns Hopkins University | Completed | No outcome recorded |
| Phase 1 | NCT01723527 Background | Dec 2012 → May 2014 | HIV infectious disease, cocaine abuse, heroin dependence | Johns Hopkins University | Completed | No outcome recorded |
| Phase 1 | NCT01560221 Background | Oct 2012 → Dec 2014 | substance-related disorder | Johns Hopkins University | Completed | No outcome recorded |
| Phase 1 | NCT00930332 Comparator | Jun 2010 → Jan 2012 | cancer of unknown primary site, sleep disorder | NCIC Clinical Trials Group | Terminated | No outcome recorded Stop: Enrollment |
| Phase 1 | NCT01099748 Comparator | May → Jun 2010 | — | Pfizer | Completed | No outcome recorded |
| Phase 1 | NCT00780702 Background | May 2008 → Apr 2013 | cocaine abuse, cocaine dependence, opiate dependence | National Institute on Drug Abuse (NIDA) | Completed | No outcome recorded |
| Phase 1/2 | NCT00838981 Comparator | May 2008 → Mar 2014 | cocaine dependence | Yale University | Completed | No outcome recorded |
| Phase 1/2 | NCT00367302 Comparator | Aug 2006 → Jan 2008 | opiate dependence | National Development and Research Institutes, Inc. | Completed | No outcome recorded |
| Phase 1/2 | NCT00249587 Background | Sep 2000 → Sep 2005 | opioid abuse | National Institute on Drug Abuse (NIDA) | Completed | No outcome recorded |
| Phase 2 | NCT05244226 Comparator | Apr 2022 → May 2023 | obstructive sleep apnea syndrome, tonsillitis | Duke University | Completed | No outcome recorded |
| Phase 2 | NCT03574792 Background | May 2018 → Apr 2021 | head and neck squamous cell carcinoma | Roswell Park Cancer Institute | Completed | No outcome recorded |
| Phase 2 | NCT00558870 Comparator | Nov 2007 → Jan 2015 | — | M.D. Anderson Cancer Center | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT00573937 Comparator | Aug 2007 → Apr 2009 | neoplasm | Mayo Clinic | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT00204243 Comparator | May 2005 → Feb 2008 | opiate dependence | University of Oslo | Completed | No outcome recorded |
| Phase 2 | NCT00142519 Comparator | Mar 2005 → Jul 2018 | — | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| Phase 2 | NCT00149630 Background | Jan 2005 → Dec 2009 | cocaine dependence, opiate dependence | Baylor College of Medicine | Completed | No outcome recorded |
| Phase 2 | NCT00000273 Background | Aug 1995 → Nov 2005 | heroin dependence | New York State Psychiatric Institute | Completed | No outcome recorded |
| Phase 2/3 | NCT05459402 Comparator | Feb 2023 → Jun 2027 expected | chronic pain syndrome, substance-related disorder | University of Maryland, Baltimore | Recruiting | No outcome recorded |
| Phase 2/3 | NCT04345718 Comparator | Aug 2021 → Aug 2025 | opiate dependence | Gavin Bart | Completed | No outcome recorded |
| Phase 3 | NCT07296770 Background | Oct 2026 → Dec 2028 expected | chronic pain syndrome | University of California, San Francisco | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07227064 Comparator | Jan → Dec 2026 expected | — | Medical University of South Carolina | Recruiting | No outcome recorded |
| Phase 3 | NCT07226076 Comparator | Jan → Dec 2026 expected | — | Medical University of South Carolina | Recruiting | No outcome recorded |
| Phase 3 | NCT05766631 Background | Jul 2023 → Jun 2027 expected | cocaine dependence, opiate dependence | Friends Research Institute, Inc. | Active not recruiting | No outcome recorded |
| Phase 3 | NCT05417100 Comparator | Jun 2022 → Jun 2027 expected | — | Memorial Sloan Kettering Cancer Center | Active not recruiting | No outcome recorded |
| Phase 3 | NCT04214834 Comparator | Sep 2020 → Jan 2024 overdue | neonatal abstinence syndrome | Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW) Program | Active not recruiting | No outcome recorded |
| Phase 3 | NCT03948464 Comparator | Dec 2019 → Jun 2020 | substance-related disorder | M. Eugenia Socias | Terminated | No outcome recorded |
| Phase 3 | NCT05164549 Comparator | Aug 2019 → Apr 2022 | — | King's College London | Completed | Met primary |
| Phase 3 | NCT02502175 Comparator | Jun 2017 → Mar 2018 | opiate dependence | University of British Columbia | Completed | Missed primary |
| Phase 3 | NCT01958476 Comparator | Sep 2013 → Mar 2017 | neonatal abstinence syndrome | Tufts Medical Center | Completed | No outcome recorded |
| Phase 3 | NCT01836328 Comparator | Aug 2011 → Jun 2015 | — | L'Hospitalet de Llobregat | Completed | No outcome recorded |
| Phase 3 | NCT01131273 Comparator | Jun 2010 → Aug 2013 | HIV infectious disease | University of Pennsylvania | Completed | No outcome recorded |
| Phase 3 | NCT01021566 Comparator | Nov 2009 → Dec 2010 | opiate dependence | First People's Hospital of Foshan | Unknown | No outcome recorded |
| Phase 3 | NCT00848419 Comparator | Apr → Dec 2009 | — | Hadassah Medical Organization | Withdrawn | No outcome recorded |
| Phase 3 | NCT00351026 Comparator | Jun 2008 → Oct 2010 | opiate dependence | University of Pennsylvania | Completed | No outcome recorded |
| Phase 3 | NCT00634010 Comparator | Feb 2008 → Jan 2015 | cancer | M.D. Anderson Cancer Center | Terminated | No outcome recorded Stop: Enrollment |
| Phase 3 | NCT01079117 Comparator | Oct 2006 → Jun 2011 | opiate dependence | Mundipharma Medical Company | Completed | No outcome recorded |
| Phase 3 | NCT00271219 Comparator | Jul 2005 → Aug 2009 | opiate dependence, pregnancy disorder | Johns Hopkins University | Completed | Mixed |
| Phase 3 | NCT00175357 Comparator | Mar 2005 → Apr 2007 | opiate dependence | University of British Columbia | Completed | Met primary |
| Phase 3 | NCT00184496 Comparator | Aug 2004 → Sep 2009 | cancer | Norwegian University of Science and Technology | Completed | No outcome recorded |
| Phase 3 | NCT00268814 Comparator | Mar 2002 → Dec 2003 | opiate dependence | University Medical Center Hamburg-Eppendorf | Completed | No outcome recorded |
| Phase 3 | NCT00004390 Background | Feb 1995 → ? | postherpetic neuralgia | National Center for Research Resources (NCRR) | Completed | No outcome recorded |
| Phase 4 | NCT07226245 Comparator | Sep → Dec 2026 expected | — | Wake Forest University Health Sciences | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07221617 Comparator | Jan → Aug 2026 overdue | neuropathy, painful | Mayo Clinic | Active not recruiting | No outcome recorded |
| Phase 4 | NCT07222072 Comparator | Nov 2025 → Oct 2027 expected | — | The Cleveland Clinic | Recruiting | No outcome recorded |
| Phase 4 | NCT06962306 Comparator | Jun 2025 → Jun 2027 expected | cleft palate | Duke University | Recruiting | No outcome recorded |
| Phase 4 | NCT06576830 Comparator | Nov 2024 → Dec 2028 expected | sleep apnea syndrome, tonsillitis | Duke University | Recruiting | No outcome recorded |
| Phase 4 | NCT05730920 Comparator | Oct 2022 → Jul 2024 | adolescent idiopathic scoliosis, juvenile idiopathic scoliosis | Dr. Casey Stondell, MD | Completed | No outcome recorded |
| Phase 4 | NCT04525898 Comparator | Oct 2019 → Feb 2021 | — | Endeavor Health | Terminated | No outcome recorded |
| Phase 4 | NCT03168958 Comparator | Dec 2018 → May 2021 overdue | — | Endeavor Health | Recruiting | No outcome recorded |
| Phase 4 | NCT03726268 Comparator | Nov 2018 → Jul 2023 | substance-related disorder | Duke University | Completed | No outcome recorded |
| Phase 4 | NCT03893734 Comparator | May 2018 → Aug 2020 overdue | long QT syndrome | Endeavor Health | Recruiting | No outcome recorded |
| Phase 4 | NCT03472469 Comparator | Apr 2018 → Jul 2019 | — | The University of Texas Health Science Center, Houston | Completed | No outcome recorded |
| Phase 4 | NCT02851303 Comparator | Oct 2016 → Jun 2018 | neonatal abstinence syndrome | University of New Mexico | Completed | No outcome recorded |
| Phase 4 | NCT03084588 Comparator | Jul 2016 → Jul 2019 | — | Endeavor Health | Unknown | No outcome recorded |
| Phase 4 | NCT03045133 Comparator | Jun → Jul 2016 | — | Pontifical Catholic University of São Paulo | Completed | No outcome recorded |
| Phase 4 | NCT01936857 Comparator | Jul 2015 → Mar 2019 | HIV infectious disease, substance-related disorder | Oregon Health and Science University | Completed | Missed primary |
| Phase 4 | NCT02206685 Comparator | May 2014 → Jan 2020 | scoliosis | Baylor College of Medicine | Completed | No outcome recorded |
| Phase 4 | NCT01733693 Comparator | Jan 2013 → Jun 2017 | HIV infectious disease, opiate dependence | Albert Einstein College of Medicine | Completed | No outcome recorded |
| Phase 4 | NCT01559454 Comparator | Feb 2012 → May 2014 | — | State University of New York at Buffalo | Completed | Missed primary |
| Phase 4 | NCT02233452 Comparator | Jan → Aug 2012 | neuropathy, painful | Federal University of Santa Maria | Completed | No outcome recorded |
| Phase 4 | NCT01804075 Comparator | Jan 2011 → Oct 2012 | neonatal abstinence syndrome | Eastern Maine Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT01047956 Background | Jun 2009 → Jun 2010 | opiate dependence | Taichung Veterans General Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT00879996 Comparator | Apr 2009 → Oct 2011 | opiate dependence | State University of New York at Buffalo | Completed | Missed primary |
| Phase 4 | NCT01723722 Comparator | Jan 2007 → Sep 2009 | neonatal abstinence syndrome | Eastern Maine Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT00315341 Comparator | Apr 2006 → Aug 2010 | opiate dependence | University of California, Los Angeles | Completed | No outcome recorded |
| — | NCT07558226 Comparator | May 2026 → Nov 2027 expected | — | Fundacio Puigvert | Recruiting | No outcome recorded |
| — | NCT03324815 Comparator | Mar 2017 → Jul 2018 | cancer | Federal University of São Paulo | Unknown | No outcome recorded |
| — | NCT02747875 Comparator | Sep 2016 → Feb 2019 | substance-related disorder | Andrew Waberski | Terminated | No outcome recorded |
| — | NCT02625181 Background | Jul 2016 → Nov 2017 | — | Vanderbilt University | Completed | No outcome recorded |
| — | NCT02300077 Comparator | Dec 2014 → Feb 2018 | — | Washington University School of Medicine | Completed | No outcome recorded |
| — | NCT01828840 Comparator | Apr 2014 → Dec 2016 | — | Hadassah Medical Organization | Completed | No outcome recorded |
| — | NCT01125059 Comparator | May 2010 → Jan 2014 | — | Northwestern University | Withdrawn | No outcome recorded Stop: Enrollment |
| — | NCT01144390 Background | Apr 2010 → Jun 2011 | heroin dependence | Shanghai Mental Health Center | Unknown | No outcome recorded |
| — | NCT00761085 Comparator | Jan 2008 → Nov 2010 | sickle cell disease | Washington University School of Medicine | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 211 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Methadone | “Methadone 30 to 130 mg will be administered as a stable oral therapy from Day -14 to Day -1, in combination with telaprevir from Day 1 to Day 7, and then alone as a continued...” NCT00933283 ↗205“The program includes medication for opioid use disorder (methadone, buprenorphine/naloxone), standardized counseling sessions (BDRC) and HIV testing and care (for people living...” NCT05368675 ↗ “The purpose of this study is to compare the clinical efficacy of the buprenorphine/naloxone combination tablet to methadone for opioid maintenance treatment.” NCT00000328 ↗ “Community standard medication for opioid use disorder (e.g., methadone, sublingual buprenorphine, naltrexone) initiated prior to hospital discharge.” NCT04345718 ↗ “plus standard methadone maintenance (daily oral methadone and weekly individual counseling).” NCT00780702 ↗ “Oral Opioids (Codeine, Tramadol, Hydrocodone, Oxycodone, Methadone, Morphine, Hydromorphone)” NCT03472469 ↗ “Methadone: 0.5-0.1mg/kg IV at the beginning of the surgical incision (single dose)” NCT07558226 ↗ “Opioids: heroin, morphine, oxycodone, hydrocodone, methadone, codeine” NCT02033707 ↗ “Filibuvir, 600mg bid administered along with methadone on days 2-11” NCT01210404 ↗ “Methadone (Dolophine®, Methadose®)” NCT06240390 ↗ “Epidural methadone bolus 4mg” NCT00848419 ↗ |
| Known as | Dolophine | “methadone (Dolophine, a long-acting narcotic)” NCT02252432 ↗1“Methadone (Dolophine®, Methadose®)” NCT06240390 ↗ |
| Known as | MET | “Participants will receive a 48-week integrated treatment program for opiate use disorder with daily directly observed oral methadone syrup (MET)” NCT04480554 ↗ |
| Known as | Methadone HCl | “Methadone HCl oral solution 5 mg/ml Methadone HCl inject 10 mg/ml (will require dilution)” NCT00715988 ↗1“IV racemic methadone HCl” NCT01648283 ↗ |
| Known as | methadone hydrochloride | “Participants will be treated/monitored overnight with Methadone hydrochloride IV (FDA approved and commercially available), with daily follow-up visits for 1 week total.” NCT05425420 ↗12“Methadone hydrochloride (0.10 mg/kg) administered intravenously at the induction of anaesthesia” NCT06086171 ↗ “Epidural bolus of 4mg of preservative free methadone hydrochloride (4mL of 1mg/mL solution)” NCT03525509 ↗ “Drug: methadone hydrochloride” NCT00726830 ↗ “Drug: Methadone hydrochloride” NCT06962306 ↗ “Drug: Methadone Hydrochloride” NCT04112550 ↗ “Drug: Methadone hydrochloride” NCT06877858 ↗ “Drug: Methadone Hydrochloride” NCT02989597 ↗ “Drug: Methadone Hydrochloride” NCT04680286 ↗ “Methadone Hydrochloride” NCT07296770 ↗ |
| Known as | Methadose | “Methadone (Dolophine®, Methadose®)” NCT06240390 ↗ |
| Known as | Methadose/ Metadol D/Compounded methadone | “Methadose/ Metadol D/Compounded methadone” NCT03948464 ↗ |
| Action | Activate | “Substitution with opioid-agonists (e.g., methadone) has shown to be an effective treatment for chronic long-term opioid dependency.” PMID 22276954 ↗ Jan 2012 |
| Modality | Other / unclassified | “Methadone is a synthetic opioid analgesic” NCT02989597 ↗ |
| Route | Oral | “The effects of p.o. methadone or sublingual buprenorphine maintenance on i.v. cocaine self-administration” PMID 8819498 ↗ Sep 1996 |