Effectiveness and Safety of Methadone Versus Placebo for the Control of Neuropathic Pain in Different Etiologies

Summary

Opioids are currently ranked as third-line agents for neuropathic pain (NP) treatment. The opioids more frequently tested for NP were tramadol, oxycodone and morphine. In the present study test the safety and effectiveness of methadone in patients with NP who remain symptomatic despite the use of first and second line drugs in a placebo-controlled randomized approach.

Timeline

Start

2019-09-06

Primary completion

2023-01-20

Completion

2023-01-20

Publications

• Pentiado Junior JAM, Barbosa MM, Kubota GT, Martins PN, Moreira LI, Fernandes AM, da Silva VA, Junior JR, Yeng LT, Teixeira MJ, Ciampi de Andrade D. METHA-NeP: effectiveness and safety of methadone for neuropathic pain: a controlled randomized trial. Pain. 2025 Mar 1;166(3):557-570. doi: 10.1097/j.pain.0000000000003413. Epub 2024 Oct 22.

Drugs

Indications