drugset / Trial / NCT00004390
Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia
Phase 3
Completed
120 enrolled
National Center for Research Resources (NCRR)
Johns Hopkins University · collabNational Institute of Neurological Disorders and Stroke (NINDS) · collab
RandomizedCrossoverDouble-blindTreatment
Summary
OBJECTIVES: I. Determine whether opioid (morphine) treatment results in better management of pain than treatment with tricyclic antidepressant (nortriptyline). II. Assess the effects the two treatments have on affective and cognitive functions. III. Determine whether the presence of psychiatric comorbidity, particularly depression, can predict the outcome of the two treatments.
Timeline
- Start
- 1995-02
- Primary completion
- —
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Morphine | Other / unclassified | — | Oral |
| Subject | Nortriptyline | Small molecule | — | Oral |
| Background | Desipramine | Small molecule | — | — |
| Background | Methadone | Other / unclassified | — | — |