Drugs / Desipramine
Desipramine
also known as
Desipramine Hydrochloride · DMI · 18-8181 · Desipramina · Desipramine hcl · EX 4355 · G-35020 · JB-8181 · +8 more
Small molecule targets SLC6A2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | NORPRAMIN | — | 1976-06-25 | fda.gov ↗ |
| Approved | US (FDA) | NORPRAMIN | — | 1964-11-20 | fda.gov ↗ |
Trials 32
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 17 trials | ||||||
| Phase 1 | NCT01358968 | Jun 2011 → Apr 2012 | cancer | Eli Lilly and Company | Completed | No outcome recorded |
| Phase 1 | NCT01153542 | Jun → Aug 2010 | cystic fibrosis | Vertex Pharmaceuticals Incorporated | Completed | No outcome recorded |
| Phase 1 | NCT01478568 | Oct 2008 → Jan 2009 | — | Astellas Pharma Inc | Completed | No outcome recorded |
| Phase 1 | NCT00500721 | Jun → Aug 2007 | — | Wyeth is now a wholly owned subsidiary of Pfizer | Completed | No outcome recorded |
| Phase 1 | NCT02273466 | Feb → Apr 2002 | — | Boehringer Ingelheim | Completed | No outcome recorded |
| Phase 1 | NCT00913822 | Dec 1987 | depressive disorder | Sandoz | Completed | No outcome recorded |
| Phase 1 | NCT00913237 | Jul → Aug 1987 | depressive disorder | Sandoz | Completed | No outcome recorded |
| Phase 210 trials · 2 missed | ||||||
| Phase 2 | NCT02436031 | Apr → Dec 2015 | obstructive sleep apnea syndrome | Brigham and Women's Hospital | Completed | Mixed |
| Phase 2 | NCT01719861 | Oct 2012 → May 2014 | small cell lung carcinoma | Joel Neal | Terminated | No outcome recorded |
| Phase 2 | NCT01411085 | Dec 2011 → Aug 2014 | alcohol dependence, schizophrenia | Dartmouth-Hitchcock Medical Center | Completed | No outcome recorded |
| Phase 2 | NCT00964886 | Jan 2010 → Dec 2014 | — | VA Office of Research and Development | Completed | Missed primary |
| Phase 2 | NCT00990691 | Feb 2009 → Aug 2014 | Rett syndrome | Assistance Publique Hopitaux De Marseille | Completed | Missed primary |
| Phase 2 | NCT00265291 | Nov 1999 → May 2006 | major depressive disorder | National Institute of General Medical Sciences (NIGMS) | Completed | No outcome recorded |
| Phase 2 | NCT00018200 | Apr 1999 → Dec 2003 | sciatica | US Department of Veterans Affairs | Completed | No outcome recorded |
| Phase 2 | NCT00000271 | Jan 1995 → Oct 2002 | cocaine abuse | New York State Psychiatric Institute | Completed | Mixed |
| Phase 2 | NCT00000245 | May 1994 → Dec 2001 | cocaine abuse | National Institute on Drug Abuse (NIDA) | Completed | No outcome recorded |
| Phase 2 | NCT00000212 | Jul 1987 → Jul 1988 | cocaine abuse | New York State Psychiatric Institute | Completed | No outcome recorded |
| Phase 34 trials · 1 met primary | ||||||
| Phase 3 | NCT01265550 | Aug 2012 → Dec 2016 | gastroesophageal reflux disease | VA Office of Research and Development | Completed | Met primary |
| Phase 3 | NCT00366652 | Sep 2006 | major depressive disorder | Wyeth is now a wholly owned subsidiary of Pfizer | Completed | No outcome recorded |
| Phase 3 | NCT00329147 | May → Jun 2006 | depressive disorder | Wyeth is now a wholly owned subsidiary of Pfizer | Completed | No outcome recorded |
| Phase 3 | NCT00006157 | Jul 1996 → Mar 2001 | constipation disorder, functional colonic disease, irritable bowel syndrome | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Completed | No outcome recorded |
| Phase 44 trials | ||||||
| Phase 4 | NCT03726996 | Jan → Aug 2019 | infantile axonal neuropathy | Duke University | Terminated | No outcome recorded Stop: Business |
| Phase 4 | NCT03548454 | Sep 2018 → Dec 2023 | chronic pain syndrome | Stanford University | Completed | No outcome recorded |
| Phase 4 | NCT00000321 | Oct 1996 → Dec 2001 | substance-related disorder | National Institute on Drug Abuse (NIDA) | Completed | No outcome recorded |
| Phase 4 | NCT00320632 | Aug 1990 → Jul 1993 | depressive disorder | Harvard Medical School (HMS and HSDM) | Completed | No outcome recorded |
| Phase not applicable7 trials · 1 missed | ||||||
| — | NCT01899326 | Sep 2013 → Mar 2015 | plasma cell myeloma | Albert Einstein College of Medicine | Terminated | No outcome recorded Stop: Enrollment |
| — | NCT00880594 | Feb 2009 → Nov 2014 | irritable bowel syndrome | Washington University School of Medicine | Terminated | No outcome recorded |
| — | NCT00456014 | Sep 2006 → May 2012 | major depressive disorder | New York State Psychiatric Institute | Completed | No outcome recorded |
| — | NCT00220844 | Sep 2005 → Jun 2014 | dyspepsia | Temple University | Terminated | No outcome recorded |
| — | NCT00276068 | Aug 2002 → Sep 2007 | vulvar disease | University of Rochester | Completed | Missed primary |
| — | NCT00018733 | Sep 1996 → Dec 2001 | depressive disorder | US Department of Veterans Affairs | Completed | No outcome recorded |
| — | NCT00000376 | Mar 1996 → Feb 1999 | anxiety disorder, major depressive disorder, personality disorder | University of Pennsylvania | Completed | No outcome recorded |
| Comparator or background therapy5 trials | ||||||
| Phase 1 | NCT01415128 Comparator | Apr → May 2010 | erectile dysfunction | VIVUS LLC | Completed | No outcome recorded |
| Phase 2 | NCT02428478 Comparator | Mar → Nov 2015 | obstructive sleep apnea syndrome | Brigham and Women's Hospital | Completed | No outcome recorded |
| Phase 3 | NCT00338962 Comparator | Oct 2001 → Jul 2015 | alcohol dependence, depressive disorder, post-traumatic stress disorder | Yale University | Completed | No outcome recorded |
| Phase 3 | NCT00004390 Background | Feb 1995 → ? | postherpetic neuralgia | National Center for Research Resources (NCRR) | Completed | No outcome recorded |
| Phase 4 | NCT00166114 Comparator | Feb 2002 → Jan 2009 | major depressive disorder | Emory University | Completed | No outcome recorded |
Evidence & citations 21 cited values
Every value below carries the sentence it was read from. 39 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Desipramine | “The current study compared the serotonin uptake inhibitor, paroxetine, to the norepinephrine uptake inhibitor, desipramine.” PMID 22089316 ↗ Nov 201135“In period 1, subjects will receive a single oral dose of desipramine on Day 1.” NCT01153542 ↗ |
| Known as | 18-8181 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Desipramina | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Desipramine hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Desipramine Hydrochloride | “desipramine hydrochloride, with dose targeted to achieve a serum concentration of 5-60ng/ml” NCT00964886 ↗3“Desipramine Hydrochloride 100 mg Tablets (Cord Laboratories)” NCT00913822 ↗ “Desipramine Hydrochloride 50 mg Tablets (Cord Laboratories)” NCT00913237 ↗ |
| Known as | DMI | “The purpose of this study is to evaluate the effects of desipramine DMI maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including...” NCT00000212 ↗1“using the standard antidepressant desipramine (DMI)” NCT00000376 ↗ |
| Known as | EX 4355 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | G-35020 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | JB-8181 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Monodemethylimipramine | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | N-desmethylimipramine | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Norimipramine | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Norpramin | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | NSC-114901 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Pertofran | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Pertofrane | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | RMI 9,384A | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Action | Inhibit | “a norepinephrine (desipramine) and a serotonin reuptake (fluoxetine) inhibitor” PMID 17414235 ↗ Apr 20071“Norepinephrine transporter inhibitor” CHEMBL72 ↗ |
| Modality | Small molecule | “Desipramine is a tricyclic antidepressant” NCT00276068 ↗ |
| Route | Oral | “oral consumption of the study agent” NCT00220844 ↗ |
| Target | SLC6A2 | “Norepinephrine transporter inhibitor” CHEMBL72 ↗ |