Drugs / Desipramine
Desipramine
also known as
Desipramine Hydrochloride · DMI · 18-8181 · Desipramina · Desipramine hcl · EX 4355 · G-35020 · JB-8181 · +8 more
Small molecule targets SLC6A2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | NORPRAMIN | — | 1976-06-25 | fda.gov ↗ |
| Approved | US (FDA) | NORPRAMIN | — | 1964-11-20 | fda.gov ↗ |
Trials 32 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 5 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT01415128 Comparator | Apr → May 2010 | erectile dysfunction | VIVUS LLC | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT02428478 Comparator | Mar → Nov 2015 | obstructive sleep apnea syndrome | Brigham and Women's Hospital | Completed | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT00338962 Comparator | Oct 2001 → Jul 2015 | alcohol dependence, depressive disorder, post-traumatic stress disorder | Yale University | Completed | No outcome recorded |
| Phase 3 | NCT00004390 Background | Feb 1995 → ? | postherpetic neuralgia | National Center for Research Resources (NCRR) | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT00166114 Comparator | Feb 2002 → Jan 2009 | major depressive disorder | Emory University | Completed | No outcome recorded |
Evidence & citations 21 cited values
Every value below carries the sentence it was read from. 39 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Desipramine | “The current study compared the serotonin uptake inhibitor, paroxetine, to the norepinephrine uptake inhibitor, desipramine.” PMID 22089316 ↗ Nov 201135“In period 1, subjects will receive a single oral dose of desipramine on Day 1.” NCT01153542 ↗ |
| Known as | 18-8181 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Desipramina | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Desipramine hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Desipramine Hydrochloride | “desipramine hydrochloride, with dose targeted to achieve a serum concentration of 5-60ng/ml” NCT00964886 ↗3“Desipramine Hydrochloride 100 mg Tablets (Cord Laboratories)” NCT00913822 ↗ “Desipramine Hydrochloride 50 mg Tablets (Cord Laboratories)” NCT00913237 ↗ |
| Known as | DMI | “The purpose of this study is to evaluate the effects of desipramine DMI maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including...” NCT00000212 ↗1“using the standard antidepressant desipramine (DMI)” NCT00000376 ↗ |
| Known as | EX 4355 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | G-35020 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | JB-8181 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Monodemethylimipramine | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | N-desmethylimipramine | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Norimipramine | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Norpramin | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | NSC-114901 | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Pertofran | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | Pertofrane | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Known as | RMI 9,384A | ChEMBL registry synonym — accepted as the source's own label CHEMBL72 ↗ |
| Action | Inhibit | “a norepinephrine (desipramine) and a serotonin reuptake (fluoxetine) inhibitor” PMID 17414235 ↗ Apr 20071“Norepinephrine transporter inhibitor” CHEMBL72 ↗ |
| Modality | Small molecule | “Desipramine is a tricyclic antidepressant” NCT00276068 ↗ |
| Route | Oral | “oral consumption of the study agent” NCT00220844 ↗ |
| Target | SLC6A2 | “Norepinephrine transporter inhibitor” CHEMBL72 ↗ |