Tricyclic Antidepressants (TCAs) on Gastric Emptying

Summary

The purpose of this study is to determine the effects of two tricyclic antidepressant agents (TCAs), amitriptyline and desipramine, on gastric emptying and gastric accommodation using a newly developed scintigraphic test that simultaneously measures both gastric emptying and gastric volume (accommodation). These two tricyclic antidepressant agents are commonly used at low doses to treat patients with refractory functional dyspepsia.

Timeline

Start

2005-09

Primary completion

2014-06

Completion

2014-06

Outcome

Outcome not reported

Stopped: “Futility; study coordinator left and were unable to continue data collection; missing data”

Drugs

Indications