drugset

drugset / Trial / NCT00000271

New Approaches to Cocaine Abuse Medications (A) - 6

NCT00000271 ↗

Phase 2 Completed 111 enrolled New York State Psychiatric Institute National Institute on Drug Abuse (NIDA) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to measure the effect of desipramine in cocaine abusers selected for major depression or dysthymia.

Timeline

Start: 1995-01
Primary completion: 2002-10
Completion: 2002-10

Outcome

Mixed primary results

paper Desipramine was associated with a higher rate of depression response (51%, 28/55) than placebo (32%, 18/56) (p < 0.05) PMID 15913920 ↗

paper but treatment groups did not differ in rate of cocaine response. PMID 15913920 ↗

Publications

Results McDowell D, Nunes EV, Seracini AM, Rothenberg J, Vosburg SK, Ma GJ, Petkova E. Desipramine treatment of cocaine-dependent patients with depression: a placebo-controlled trial. Drug Alcohol Depend. 2005 Nov 1;80(2):209-21. doi: 10.1016/j.drugalcdep.2005.03.026.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Desipramine	Small molecule	300 mg	—

Indications