Efficacy of Antidepressants in Chronic Back Pain

Phase 2 Completed 142 enrolled VA Office of Research and Development University of California, San Diego · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

This 12 week placebo controlled clinical trial tests the individual and combined effects of an antidepressant medication and cognitive behavioral therapy for chronic back pain.

Timeline

Start: 2010-01
Primary completion: 2014-12
Completion: 2015-12

Outcome

Missed primary endpoint

registry analysis (superiority or other test); Arm 1 + Arm 3 vs Arm 2 + Arm 4; p = 0.7; ANCOVA NCT00964886 ↗

registry analysis (superiority or other test); Arm 2 + Arm 3 vs Arm 1 + Arm 4; p = 0.6; ANCOVA NCT00964886 ↗

paper intent-to-treat analyses at post-treatment showed no significant differences between any condition PMID 32068667 ↗

Publications

Gould HM, Atkinson JH, Chircop-Rollick T, D'Andrea J, Garfin S, Patel SM, Funk SD, Capparelli EV, Penzien DB, Wallace M, Weickgenanta AL, Slater M, Rutledge T. A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain. Pain. 2020 Jun;161(6):1341-1349. doi: 10.1097/j.pain.0000000000001834.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Desipramine	Small molecule	—	—

Indications

No indication recorded.