Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone

Completed 113 enrolled Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

RandomizedParallel-groupDouble-blindTreatment

Summary

Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery. Methadone is both a µ-opioid receptor agonist like Morphine and a N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia after abdominal surgery.

Timeline

Start: 2009-12-01
Primary completion: 2012-06-01
Completion: 2014-08-01

Publications

Tognoli E, Proto PL, Motta G, Galeone C, Mariani L, Valenza F. Methadone for postoperative analgesia: contribution of N-methyl-D-aspartate receptor antagonism: A randomised controlled trial. Eur J Anaesthesiol. 2020 Oct;37(10):934-943. doi: 10.1097/EJA.0000000000001217.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	2 ug/kg	—
Subject	Methadone	Other / unclassified	2 mg	—

Indications

No indication recorded.