drugset / Trial / NCT03472469
MAST Trial: Multi-modal Analgesic Strategies in Trauma
Phase 4
Completed
1561 enrolled
The University of Texas Health Science Center, Houston
National Center for Advancing Translational Sciences (NCATS) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared \[original multimodal pain regimen (MMPR) compared to multi-modal analgesic strategies for trauma (MAST) MMPR\].
Timeline
- Start
- 2018-04-02
- Primary completion
- 2019-07-03
- Completion
- 2019-07-03
Publications
- Background Harvin JA, Green CE, Vincent LE, Motley KL, Podbielski J, Miller CC, Tyson JE, Holcomb JB, Wade CE, Kao LS. Multi-modal Analgesic Strategies for Trauma (MAST): protocol for a pragmatic randomized trial. Trauma Surg Acute Care Open. 2018 Aug 19;3(1):e000192. doi: 10.1136/tsaco-2018-000192. eCollection 2018.
- Results Harvin JA, Albarado R, Truong VTT, Green C, Tyson JE, Pedroza C, Wade CE, Kao LS; MAST Study Group. Multi-Modal Analgesic Strategy for Trauma: A Pragmatic Randomized Clinical Trial. J Am Coll Surg. 2021 Mar;232(3):241-251.e3. doi: 10.1016/j.jamcollsurg.2020.12.014. Epub 2021 Jan 21.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | 1 g | Intravenous |
| Comparator | Celecoxib | Other / unclassified | 200 mg | Oral |
| Comparator | Gabapentin | Small molecule | 300 mg | Oral |
| Comparator | Naproxen | Small molecule | 500 mg | Oral |
| Comparator | Pregabalin | Small molecule | 100 mg | Oral |
| Comparator | Tramadol | Other / unclassified | 100 mg | Oral |
| Comparator | Codeine | Small molecule | — | Oral |
| Comparator | Fentanyl | Other / unclassified | — | Topical |
| Comparator | Hydrocodone | Unknown | — | Oral |
| Comparator | Hydromorphone | Other / unclassified | — | Oral |
| Comparator | Ketorolac | Other / unclassified | 30 mg | Intravenous |
| Comparator | Lidocaine | Other / unclassified | — | Topical |
| Comparator | Methadone | Other / unclassified | — | Oral |
| Comparator | Morphine | Other / unclassified | — | Oral |
| Comparator | Oxycodone | Other / unclassified | — | Oral |
Indications
No indication recorded.