drugset / Trial / NCT04526236
Influence of Aging on Perioperative Methadone Dosing
RandomizedParallel-groupDouble-blindTreatment
Summary
Increasingly, elderly patients undergo anesthesia and surgery. Methadone is a great opioid for perioperative pain management, however, to date there are no pharmacokinetic or pharmacodynamic studies that asses a methadone dose adjustment in the elderly patient. The present study is aimed to characterize the pharmacokinetic and pharmacodynamic age-related changes of methadone in the adult population and further to design reference dosing protocols for intraoperative methadone use according to patient age.
Timeline
- Start
- 2019-09-03
- Primary completion
- 2022-07-13
- Completion
- 2022-07-13
Publications
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