drugset / Trial / NCT01559454
Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients
RandomizedParallel-groupOpen-labelTreatment
Summary
Chronic pain patients are treated with prescription opioids and many exhibit opioid addiction. Currently, there are no evidence-based guidelines to better manage patients with chronic pain and coexistent opioid addiction. This study compares 6-months buprenorphine and methadone treatment in these patients. The investigators hypothesize that both buprenorphine and methadone treatment will reduce pain and addiction behaviors and increase functioning in these patients.
Timeline
- Start
- 2012-02
- Primary completion
- 2014-05
- Completion
- 2014-05
Publications
- Background Neumann AM, Blondell RD, Jaanimagi U, Giambrone AK, Homish GG, Lozano JR, Kowalik U, Azadfard M. A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction. J Addict Dis. 2013;32(1):68-78. doi: 10.1080/10550887.2012.759872.
- Nielsen S, Tse WC, Larance B. Opioid agonist treatment for people who are dependent on pharmaceutical opioids. Cochrane Database Syst Rev. 2022 Sep 5;9(9):CD011117. doi: 10.1002/14651858.CD011117.pub3.
- Neumann AM, Blondell RD, Hoopsick RA, Homish GG. Randomized clinical trial comparing buprenorphine/naloxone and methadone for the treatment of patients with failed back surgery syndrome and opioid addiction. J Addict Dis. 2020 Jan-Mar;38(1):33-41. doi: 10.1080/10550887.2019.1690929. Epub 2019 Nov 27.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Buprenorphine | Other / unclassified | 4 mg | — |
| Subject | Buprenorphine | Other / unclassified | 16 mg | — |
| Comparator | Methadone | Other / unclassified | 10 mg | — |
| Comparator | Methadone | Other / unclassified | 60 mg | — |
| Background | Naloxone | Small molecule | — | — |
Indications
No indication recorded.