drugset / Trial / NCT01936857
Buprenorphine to Improve HIV Care Engagement and Outcomes
Phase 4
Completed
281 enrolled
Oregon Health and Science University
Hanoi Medical University · collabHennepin Healthcare Research Institute · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to compare two models of substance abuse treatment in Vietnam, and how they each affect HIV care. In Vietnam, the current model for treating people with HIV who are also dependent on opioids is to refer them to methadone maintenance treatment centers. The new model the protocol will study is treatment of HIV and opioid dependence with buprenorphine/naloxone and counseling in the HIV clinic.
Timeline
- Start
- 2015-07
- Primary completion
- 2019-03
- Completion
- 2019-04
Publications
- Edsall A, Hoffman KA, Thuy DT, Mai PP, Hang NT, Khuyen TT, Trang NT, Kunkel LE, Giang LM, Korthuis PT. Use of methamphetamine and alcohol among people with opioid use disorder and HIV in Vietnam: a qualitative study. BMC Public Health. 2021 Sep 22;21(1):1718. doi: 10.1186/s12889-021-11783-9.
- Korthuis PT, King C, Cook RR, Khuyen TT, Kunkel LE, Bart G, Nguyen T, Thuy DT, Bielavitz S, Nguyen DB, Tam NTM, Giang LM. HIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial. Lancet HIV. 2021 Feb;8(2):e67-e76. doi: 10.1016/S2352-3018(20)30302-7.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Buprenorphine/naloxone | Unknown | 8 mg | — |
| Subject | Buprenorphine/naloxone | Unknown | 24 mg | — |
| Comparator | Methadone | Other / unclassified | — | — |