Divided or Single Exposure (DOSE) Study

Summary

This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.

Timeline

Start

2023-02-21

Primary completion

2027-06-01

Completion

2028-06-01

Publications

• McKendrick G, Davis W, Sklar M, Brown N, Pattillo E, Finan PH, Antoine D, Walters V, Dunn KE. The IMPOWR Network Divided or Single Exposure Study (DOSE) Protocol: A Randomized Controlled Comparison of Once Versus Split Dosing of Methadone for the Treatment of Comorbid Chronic Pain and Opioid Use Disorder. Subst Use Addctn J. 2025 Jan;46(1):197-200. doi: 10.1177/29767342241239167. Epub 2024 Mar 25.

Drugs

Indications