Methadone in TKA for Post-op Pain and Opioid Reduction

Phase 3 Recruiting 162 enrolled Medical University of South Carolina

RandomizedParallel-groupDouble-blindTreatment

Summary

This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.

Timeline

Start: 2026-01-08
Primary completion: 2026-12-28
Completion: 2027-01-15

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Methadone	Other / unclassified	0.15 mg/kg	Intravenous

Indications

No indication recorded.