drugset / Trial / NCT00879996
Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients
Phase 4
Completed
54 enrolled
State University of New York at Buffalo
National Institute on Alcohol Abuse and Alcoholism (NIAAA) · collabNational Institute on Drug Abuse (NIDA) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to determine if buprenorphine or methadone is better for the treatment of chronic pain among patients who have become addicted to prescription narcotics.
Timeline
- Start
- 2009-04
- Primary completion
- 2011-10
- Completion
- 2011-10
Outcome
Missed primary endpoint
registry analysis (superiority or other test); Methadone vs Buprenorphine/Naloxone; p = 0.77; Hazard Ratio (HR) 0.9134 (95% CI 0.4156 to 2.007); Log Rank NCT00879996 ↗
Publications
- Nielsen S, Tse WC, Larance B. Opioid agonist treatment for people who are dependent on pharmaceutical opioids. Cochrane Database Syst Rev. 2022 Sep 5;9(9):CD011117. doi: 10.1002/14651858.CD011117.pub3.
- Neumann AM, Blondell RD, Jaanimagi U, Giambrone AK, Homish GG, Lozano JR, Kowalik U, Azadfard M. A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction. J Addict Dis. 2013;32(1):68-78. doi: 10.1080/10550887.2012.759872.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Buprenorphine | Other / unclassified | — | Other |
| Comparator | Methadone | Other / unclassified | — | Oral |
| Subject | Naloxone | Small molecule | — | Other |