Methadone for Postoperative Pain

Completed 86 enrolled Universidad de Valparaiso

RandomizedParallel-groupDouble-blindTreatment

Summary

The aim of this study is to compare the efficacy of methadone versus morphine in dealing with postoperative pain, in laparoscopic cholecystectomy under total intravenous anesthesia (TIVA); Efficacy is defined in terms of the difference of milligrams in morphine used as rescue analgesia postoperatively. Our hypothesis is that methadone is more effective than morphine for postoperative pain treatment.

Timeline

Start: 2013-03
Primary completion: 2013-08
Completion: 2013-09

Publications

Background Arriaza N, Papuzinski C, Kirmayr M, Matta M, Aranda F, Stojanova J, Madrid E. Efficacy of methadone for the management of postoperative pain in laparoscopic cholecystectomy: A randomized clinical trial. Medwave. 2021 Mar 23;21(2):e8135. doi: 10.5867/medwave.2021.02.8134. English, Spanish.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Methadone	Other / unclassified	0.08 mg/kg	—
Comparator	Morphine	Other / unclassified	0.08 mg/kg	—
Background	Propofol	Small molecule	—	Intravenous
Background	Remifentanil	Small molecule	—	Intravenous

Indications

No indication recorded.