drugset / Trial / NCT02687347
Efficacy and Safety of Ultra-low Dose Methadone as Adjuvant Analgesic in Cancer Patients With Pain
Phase 3
Unknown
204 enrolled
McGill University Health Centre/Research Institute of the McGill University Health Centre
RandomizedParallel-groupQuadruple-blindSupportive care
Summary
The research hypothesis of this study is: In patients with moderate to severe cancer related pain, the addition of low dose methadone to an existing opioid significantly reduces pain severity compared to low doses morphine.
Timeline
- Start
- 2016-02
- Primary completion
- 2018-02
- Completion
- 2018-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methadone | Other / unclassified | 1 mg | Oral |
| Subject | Methadone | Other / unclassified | 10 mg | Oral |
| Comparator | Morphine | Other / unclassified | 1 mg | Oral |
| Comparator | Morphine | Other / unclassified | 10 mg | Oral |