drugset

drugset / Trial / NCT04254731

Effects of Switching From Racemic Methadone to R-methadone on QTc Intervals

NCT04254731 ↗

Phase 4 Unknown 10 enrolled Oslo University Hospital

NaSingle-groupOpen-labelTreatment

Summary

Effects of switching from racemic methadone to R-methadone on serum methadone concentrations and QTc intervals

Timeline

Start: 2015-05-07
Primary completion: 2018-06-27
Completion: 2024-07-30

Publications

Background Havig SM, Berg-Pedersen RM, Krabseth HM, Muller LD, Haugaa K, Zare HK, Gjesdal K, Krajci P, Opdal MS. Effect on QTc interval by switching from methadone to equipotent R-methadone dose in methadone maintenance treatment patients. Basic Clin Pharmacol Toxicol. 2024 Apr;134(4):519-530. doi: 10.1111/bcpt.13982. Epub 2024 Feb 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levomethadone	Small molecule	—	—
Subject	Methadone	Other / unclassified	—	—

Indications