drugset / Trial / NCT01389544
A Study on the Interaction Between Danoprevir/Ritonavir and Methadone
NaSingle-groupOpen-label
Summary
This multicenter, open-label study will assess the effect of multiple doses of danoprevir/ritonavir on steady-state pharmacokinetics of methadone. Subjects on stable methadone maintenance therapy (20 - 120 mg daily as single oral morning dose) will receive danoprevir 100 mg orally twice daily and ritonavir 100 mg orally twice daily for 10 days.
Timeline
- Start
- 2011-06
- Primary completion
- 2011-07
- Completion
- 2011-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methadone | Other / unclassified | 20 mg | Oral |
| Subject | Methadone | Other / unclassified | 120 mg | Oral |
| Subject | Ritonavir | Other / unclassified | 100 mg | Oral |
| Subject | danoprevir | Small molecule | 100 mg | Oral |
Indications
No indication recorded.