A Study to Investigate the Potential Interaction Between Telaprevir and Methadone, at Steady-State

Phase 1 Completed 18 enrolled Tibotec BVBA Vertex Pharmaceuticals Incorporated · collab

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to evaluate the effect of steady-state (constant concentration of medication in the blood) telaprevir 750 mg every 8 hours on the steady-state pharmacokinetics (how the drug concentrations change over time) of R- and S-methadone.

Timeline

Start: 2009-07
Primary completion: 2009-11
Completion: 2009-12

Publications

van Heeswijk R, Verboven P, Vandevoorde A, Vinck P, Snoeys J, Boogaerts G, De Paepe E, Van Solingen-Ristea R, Witek J, Garg V. Pharmacokinetic interaction between telaprevir and methadone. Antimicrob Agents Chemother. 2013 May;57(5):2304-9. doi: 10.1128/AAC.02262-12. Epub 2013 Mar 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Methadone	Other / unclassified	30 mg	Oral
Subject	Methadone	Other / unclassified	130 mg	Oral
Subject	Telaprevir	Small molecule	750 mg	Oral

Indications

No indication recorded.