Methadone Versus Morphine for Orthopedic Surgery Patients

Phase 4 Completed 75 enrolled University of Louisville

RandomizedParallel-groupTriple-blindTreatment

Summary

The investigators propose to compare analgesia by methadone and ketamine with a combination of morphine and ketamine in orthopedic surgery patients with moderate to severe pain. The investigators hypothesize that when given with ketamine before surgical incision, methadone is more effective than morphine in reducing postoperative morphine consumption and reducing pain during movement.

Timeline

Start: 2009-01
Primary completion: 2013-12
Completion: 2013-12

Outcome

Met primary endpoint

registry MEAN Methadone: 51 (Standard Deviation 19) mg MEAN Control: 87 (Standard Deviation 40) mg analysis (superiority test); Methadone vs Control; p = 0.0072; ANOVA NCT00892606 ↗

Publications

Background Wadhwa A, Clarke D, Goodchild CS, Young D. Large-dose oral dextromethorphan as an adjunct to patient-controlled analgesia with morphine after knee surgery. Anesth Analg. 2001 Feb;92(2):448-54. doi: 10.1097/00000539-200102000-00032.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Methadone	Other / unclassified	0.2 mg/kg	Intravenous
Comparator	Morphine	Other / unclassified	0.2 mg/kg	Intravenous

Indications

No indication recorded.