Pediatric Pain Optimization After Tonsillectomy

Phase 2 Completed 66 enrolled Duke University

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery.

Timeline

Start: 2022-04-08
Primary completion: 2023-05-10
Completion: 2023-05-10

Publications

Results Einhorn LM, Hoang J, La JO, Kharasch ED. Single-dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double-blind Clinical Trial. Anesthesiology. 2024 Sep 1;141(3):463-474. doi: 10.1097/ALN.0000000000005031.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Fentanyl	Other / unclassified	—	—
Comparator	Hydromorphone	Other / unclassified	—	—
Comparator	Methadone	Other / unclassified	0.1 mg/kg	Intravenous
Comparator	Methadone	Other / unclassified	0.15 mg/kg	Intravenous

Pediatric Pain Optimization After Tonsillectomy

Summary

Timeline

Publications

Drugs

Indications