drugset / Trial / NCT07226245
Methadone Pharmacokinetics in Cardiac Surgery
RandomizedParallel-groupOpen-labelTreatment
Summary
Cardiac surgery frequently leads to significant postoperative pain, with multiple different drug regimens being utilized (both opioid and non-opioid) in an attempt to alleviate this surgical pain. Methadone is currently one of the drugs that is being utilized to help control the pain. It can be given during and/or after surgery. This study hopes to identify the optimal dose of methadone to use to treat this surgical pain.
Timeline
- Start
- 2026-09
- Primary completion
- 2026-12-30
- Completion
- 2026-12-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Methadone | Other / unclassified | 0.1 mg/kg | — |
| Comparator | Methadone | Other / unclassified | 0.15 mg/kg | — |
| Comparator | Methadone | Other / unclassified | 0.2 mg/kg | — |
| Comparator | Methadone | Other / unclassified | 0.3 mg/kg | — |
Indications
No indication recorded.