Opioid Rotation From Morphine to Methadone in Treatment of Non-malignant Pain

Summary

Patients with non-malignant pain are switched from morphine to methadone with a nine-months' follow-up.

Timeline

Start

2004-01

Primary completion

2005-03

Completion

2005-03

Publications

• Background Fredheim OM, Borchgrevink PC, Hegrenaes L, Kaasa S, Dale O, Klepstad P. Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: A prospective 9-month follow-up study. J Pain Symptom Manage. 2006 Aug;32(2):180-5. doi: 10.1016/j.jpainsymman.2006.02.010.
• Results Fredheim OM, Kaasa S, Dale O, Klepstad P, Landro NI, Borchgrevink PC. Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study. Palliat Med. 2006 Jan;20(1):35-41. doi: 10.1191/0269216306pm1099oa.

Drugs

Indications