PO Methadone Ortho Outpatient

Phase 3 Not yet recruiting 100 enrolled Keck School of Medicine of USC

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The goal of this clinical trial is to learn if oral methadone given before surgery works to minimize post-operative pain and opioid usage. The main questions it aims to answer are: Does oral methadone improve post-operative pain scores as compared to standard treatment? Does oral methadone lead to reduced use of post-operative and post-discharge opioid usage as compared to the current standard treatment? Researchers will compare oral methadone to a placebo (a look-alike substance that contains no drug) to assess the questions above. Participants will: Receive either oral methadone or a look-alike placebo before surgery Receive standard intraoperative and immediate post-operative pain control at the anesthesiologist's discretion Be asked about their pain levels in the recovery area Keep a diary of pain and opioid usage over the first 2 days after surgery

Timeline

Start: 2025-05-01
Primary completion: 2025-12-01
Completion: 2025-12-15

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Methadone	Other / unclassified	5 mg	Oral
Subject	Methadone	Other / unclassified	10 mg	Oral

Indications

No indication recorded.