Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia
Summary
Maternal hypotension is the most frequent complication of a spinal Anesthesia. The prevention of spinal hypotension appears more likely to decrease the frequency and severity of associated adverse maternal symptoms than the treatment of established hypotension. Intravenous fluid administration prior to spinal anesthesia for caesarean section is accepted standard practice. The choice of fluid depends on individual and institutional habit, material cost (crystalloid is considerably cheaper) and the perceived relative benefits and risks. Uncommon but potentially serious adverse effect of colloids is impaired coagulation. Although pregnancy is associated with hypercoagulability, little is known about the effects of colloid preloading on coagulation in pregnant patients.
Timeline
- Start
- 2016-01
- Primary completion
- 2016-07
- Completion
- 2016-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | hydroxyethyl starch | Other / unclassified | 500 ml | — |
| Comparator | Atropine | Other / unclassified | 0.5 mg | Intravenous |
| Comparator | Bupivacaine | Other / unclassified | 10 mg | Intrathecal |
| Comparator | Bupivacaine | Other / unclassified | 12 mg | Intrathecal |
| Comparator | Ephedrine | Small molecule | 6 mg | Intravenous |
| Comparator | Morphine | Other / unclassified | 200 ug | Intrathecal |
| Comparator | sodium chloride | Unknown | 10 unknown | — |