Prophylactic Norepinephrine Infusion Combined With Colloid Coloading for Postspinal Anesthesia Hypotension

Completed 175 enrolled General Hospital of Ningxia Medical University

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to investigate the suitable infusion dose of prophylactic norepinephrine infusion combined with 6% Hydroxyethyl starch (130/0.4) coload for post-spinal anesthesia hypotension in patients undergoing cesarean section.

Timeline

Start: 2021-11-26
Primary completion: 2022-09-03
Completion: 2022-09-03

Publications

Guo L, Xiong X, Qin R, Li Z, Shi Y, Xue W, He L, Ma S, Chen Y. Prophylactic norepinephrine combined with 6% hydroxyethyl starch (130/0.4) co-load infusion for preventing postspinal anesthesia hypotension during cesarean section: a randomized, controlled, dose-finding trial. Daru. 2024 Jun;32(1):1-9. doi: 10.1007/s40199-023-00479-7. Epub 2023 Oct 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Norepinephrine	Other / unclassified	0.025 ug/kg	Intravenous
Subject	Norepinephrine	Other / unclassified	0.05 ug/kg	Intravenous
Subject	Norepinephrine	Other / unclassified	0.075 ug/kg	Intravenous
Subject	Norepinephrine	Other / unclassified	0.1 ug/kg	Intravenous

Indications

No indication recorded.