Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock

Phase 2/3 Completed 330 enrolled University of Versailles Assistance Publique - Hôpitaux de Paris · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Catecholamines infusion is a major component of septic shock management. International guidelines recommend that norepinephrine should be preferred to epinephrine, though phase III trials are lacking. The present study aimed at comparing the efficacy and safety of norepinephrine plus dobutamine to that of epinephrine in adults with septic shock.

Timeline

Start: 1999-10
Primary completion: 2004-12
Completion: 2005-12

Outcome

Missed primary endpoint

paper At day 28, there were 64 (40%) deaths in the epinephrine group and 58 (34%) deaths in the norepinephrine plus dobutamine group (p=0.31; PMID 17720019 ↗

Publications

Results Annane D, Vignon P, Renault A, Bollaert PE, Charpentier C, Martin C, Troche G, Ricard JD, Nitenberg G, Papazian L, Azoulay E, Bellissant E; CATS Study Group. Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. Lancet. 2007 Aug 25;370(9588):676-84. doi: 10.1016/S0140-6736(07)61344-0.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dobutamine	Small molecule	—	Other
Comparator	Epinephrine	Other / unclassified	—	—
Subject	Norepinephrine	Other / unclassified	—	Other