drugset / Trial / NCT03680404
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction
RandomizedParallel-groupOpen-labelBasic science
Summary
The goal of this study is to examine possible mechanisms of heightened vasoconstriction in Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease. The main targets in this study are sources of oxidative stress.
Timeline
- Start
- 2018-10-01
- Primary completion
- 2020-02-01
- Completion
- 2020-02-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Allopurinol | Small molecule | 1e-05 unknown | — |
| Subject | Apocynin | Small molecule | 0.0001 unknown | — |
| Comparator | Phenylephrine | Small molecule | 1e-08 unknown | — |
| Comparator | Phenylephrine | Small molecule | 1e-07 unknown | — |
| Comparator | Phenylephrine | Small molecule | 1e-06 unknown | — |
| Comparator | Phenylephrine | Small molecule | 1e-05 unknown | — |
| Comparator | Phenylephrine | Small molecule | 0.0001 unknown | — |
| Comparator | Phenylephrine | Small molecule | 0.001 unknown | — |
| Comparator | Phenylephrine | Small molecule | 0.01 unknown | — |
| Subject | Tempol | Small molecule | 1e-05 unknown | — |