Drugs / Apocynin
Apocynin
also known as
1-(4-Hydroxy-3-methoxyphenyl)ethanone · 4-hydroxy-3-methoxyacetophenone · 4H3MA · Acetovanillone · NSC-209524
Trials 6 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 15 trials | ||||||
| Phase 1 | NCT03680404 | Oct 2018 → Feb 2020 | vascular disorder | The University of Texas at Arlington | Completed | No outcome recorded |
| Phase 1 | NCT03680573 | Jan → May 2018 | cardiovascular disorder | The University of Texas at Arlington | Completed | No outcome recorded |
| Phase 1 | NCT03680638 | Sep 2016 → Oct 2017 | cardiovascular disorder, isoproterenol-mediated vasodilatation | The University of Texas at Arlington | Completed | No outcome recorded |
| Phase 1 | NCT01402297 | Oct 2010 → Jan 2011 | chronic obstructive pulmonary disease | Medical University of Lodz | Completed | No outcome recorded |
| Phase 1 | NCT00992667 | Jun → Aug 2008 | asthma | Medical University of Lodz | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT04657926 | Sep 2020 → Sep 2021 | osteoarthritis, knee | AKL Research and Development | Completed | No outcome recorded |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 8 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Apocynin | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03680638 ↗ |
| Known as | 1-(4-Hydroxy-3-methoxyphenyl)ethanone | “This site will only be infused with apocynin (1-(4-Hydroxy-3-methoxyphenyl)ethanone; 100µM) during the local heating stimulus.” NCT03680638 ↗1“This site will receive 100 µM apocynin (1-(4-Hydroxy-3-methoxyphenyl)ethanone) at an infusion rate of 2 µl/min.” NCT03680573 ↗ |
| Known as | 4-hydroxy-3-methoxyacetophenone | “4-hydroxy-3-methoxyacetophenone (4H3MA)” NCT04657926 ↗ |
| Known as | 4H3MA | “4-hydroxy-3-methoxyacetophenone (4H3MA)” NCT04657926 ↗ |
| Known as | Acetovanillone | ChEMBL registry synonym — accepted as the source's own label CHEMBL346919 ↗ |
| Known as | NSC-209524 | ChEMBL registry synonym — accepted as the source's own label CHEMBL346919 ↗ |
| Action | Inhibit | “Apocynin is an inhibitor of NADPH oxidase present in inflammatory cells such as eosinophils and neutrophils.” PMID 11728816 ↗ Dec 2001 |
| Modality | Small molecule | — CHEMBL346919 ↗ |
| Route | Inhaled | “The aim of the study is to investigate the effect of inhaled apocynin on ROS (reactive oxygen species) and NOS (reactive nitrogen species) synthesis in 10 nonsmoking mild asthmatics.” NCT00992667 ↗ |