drugset / Trial / NCT02885168
Modulation of Vasoreactivity in Septic Shock: Impact of Recombinant Protein C
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The purpose is to demonstrate that vasoreactivity of patients with septic shock evaluated with dose-response curve is diminished in septic shock and ameliorated by activated protein C (APC). This amelioration is correlated to decrease of inflammation, decrease of reactive oxygen species (ROS) markers and increase of circulating catecholamines.
Timeline
- Start
- 2008-02
- Primary completion
- 2009-04
- Completion
- 2009-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Drotrecogin alfa (activated) | Protein / enzyme biologic | 24 ug/kg | Intravenous |
| Subject | Phenylephrine | Small molecule | 0 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 0.02 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 0.05 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 0.1 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 0.2 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 0.5 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 0.75 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 1 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 1.5 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 3 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 4.5 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 6 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 9 ug/kg | — |
| Subject | Phenylephrine | Small molecule | 12 ug/kg | — |