drugset / Trial / NCT03972683
Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training
NaSingle-groupOpen-labelBasic science
Summary
The overall goal of this study is to address fundamental questions regarding how the molecule acetylcholine interacts with the sympathetic nervous system to regulate blood flow and oxygen delivery to working skeletal muscle in young and older adults. With advancing age, blood vessels supplying active muscle lose their ability to override sympathetic constriction, which limits delivery of oxygen and results in fatigue. Findings from these studies will serve as the foundation for new strategies to improve regional blood flow regulation in older adults and clinical populations, which will increase quality of life and help to preserve functional independence.
Timeline
- Start
- 2019-04-16
- Primary completion
- 2021-07-31
- Completion
- 2021-07-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetylcholine | Small molecule | 0.5 ug | Other |
| Subject | Acetylcholine | Small molecule | 1.5 ug | Other |
| Subject | Acetylcholine | Small molecule | 15 ug | Other |
| Subject | Atropine | Other / unclassified | 0.067 mg | Other |
| Subject | Phenylephrine | Small molecule | 0.125 ug | Other |
| Subject | Phenylephrine | Small molecule | 0.25 ug | Other |
| Subject | Sodium Nitroprusside | Unknown | 1 ug | Other |
| Subject | adenosine triphosphate | Small molecule | 10 ug | Other |
Indications
No indication recorded.