Drugs / Isoproterenol
Isoproterenol
Regulatory milestones approvals, filings & regulatory actions · 3 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (2) | US (FDA) | ISUPREL | — | 1986-10-08 – 1999-05-04 | fda.gov ↗ |
| Approved | US (FDA) | ISUPREL | — | 1948-02-19 | fda.gov ↗ |
Trials 15 · a red edge is where a trial was stopped
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 03 trials | ||||||
| Phase 0 | NCT06520982 | Sep 2024 → Jun 2027 expected | sympathetic nervous system disorder | University of Missouri-Columbia | Recruiting | No outcome recorded |
| Phase 0 | NCT05219799 | Mar 2023 → Jun 2026 overdue | isoproterenol-mediated vasodilatation, obesity disorder | University of Missouri-Columbia | Recruiting | No outcome recorded |
| Phase 0 | NCT06643221 | Jan 2018 → May 2031 expected | leukemia, lymphoma | University of Arizona | Recruiting | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT02833207 | Apr 2012 → Nov 2021 | obesity disorder | University of Wisconsin, Madison | Terminated | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00624416 | Oct 2007 → Mar 2009 | lipoma | Pennington Biomedical Research Center | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT00323843 | Jun 2006 → Feb 2007 | urolithiasis | Fredericia Hosptial | Unknown | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT06473116 | Mar 2025 → Jul 2029 expected | cardiac arrest | University of Southern Denmark | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT05997732 | Oct 2023 → Dec 2027 expected | — | University of Alberta | Recruiting | No outcome recorded |
| Phase 4 | NCT05658692 | Oct 2022 → Oct 2023 | acute respiratory distress syndrome | Second Affiliated Hospital, School of Medicine, Zhejiang University | Unknown | No outcome recorded |
| Phase not applicable6 trials | ||||||
| — | NCT03019081 | Jan 2017 → Aug 2021 | anorexia nervosa | Laureate Institute for Brain Research, Inc. | Unknown | No outcome recorded |
| — | NCT02725060 | Feb 2016 → Oct 2026 expected | cardiac rhythm disease, postural orthostatic tachycardia syndrome, primary dysautonomia | Vanderbilt University Medical Center | Enrolling by invitation | No outcome recorded |
| — | NCT02615119 | Oct 2015 → Jun 2023 | anorexia nervosa, brain injury, generalized anxiety disorder, major depressive disorder +1 | Laureate Institute for Brain Research, Inc. | Completed | No outcome recorded |
| — | NCT02524145 | Jun 2015 → Nov 2017 | heart failure | University of Texas Southwestern Medical Center | Completed | No outcome recorded |
| — | NCT01377636 | Aug 2009 → Sep 2011 | — | NYU Langone Health | Completed | No outcome recorded |
| — | NCT00226551 | Aug 1999 → ? | coronary artery disorder | Hadassah Medical Organization | Completed | No outcome recorded |
Also used as a comparator or background therapy in 8 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT00748059 Background | Dec 1996 → Dec 2020 | autonomic nervous system disorder, disorder of catecholamine synthesis, orthostatic hypotension | Vanderbilt University Medical Center | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT03032965 Background | Oct 2011 → Jul 2015 | paroxysmal atrial fibrillation | University of Michigan | Completed | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT00428428 Comparator | Feb → Nov 2007 | benign urinary system neoplasm, urolithiasis | Fredericia Hosptial | Completed | No outcome recorded |
| Phase not applicable5 trials | ||||||
| — | NCT06082388 Comparator | Nov 2023 → Sep 2025 | cardiac rhythm disease | Medical University of Lodz | Unknown | No outcome recorded |
| — | NCT04950881 Background | Jul 2021 → Dec 2022 | — | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | Unknown | No outcome recorded |
| — | NCT04274413 Background | Feb 2021 | CFTR-related disorder, cystic fibrosis | The Hospital for Sick Children | Withdrawn | No outcome recorded |
| — | NCT02726620 Background | Jan → Dec 2017 | hypotensive disorder | Vanderbilt University Medical Center | Completed | No outcome recorded |
| — | NCT02310789 Background | Jul 2015 → Aug 2016 | cystic fibrosis | Richard Barry Moss | Completed | No outcome recorded |
Evidence & citations 61 cited values
Every value below carries the sentence it was read from. 25 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Isoproterenol | “Lastly, beta-adrenergic sweating will be stimulated by injecting a combination of the following drugs: atropine, isoproterenol, and aminophylline (β-cocktail).” NCT04274413 ↗20“Agonists include: ATP, Bradykinin (BK), Isoproterenol (ISO), and Acetylcholine (Ach), will be infused 3 times each (order randomized).” NCT02833207 ↗ “atropine (0.01-0.02mg/kg) or isoproterenol (1-2 μg/per time)is given intravenously to increase the heart rate.” NCT04950881 ↗ “Cocktail composed of atropine (280µM), isoproterenol (160µM), and aminophylline (20 mM).” NCT02310789 ↗ “isoproterenol” NCT05658692 ↗ |
| Known as | Aerolone | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Aerotrol | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Aleudrin | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Aludrin | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Aludrine | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Asiprenol | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Asmalar | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Assiprenol | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Bellasthman | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Dl-isoprenaline hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Euspiran | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Imuprel | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isomenyl | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isomist | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isonorin | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoprenalina | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoprenaline | ClinicalTrials.gov intervention name — accepted as the source's own label NCT06082388 ↗ |
| Known as | Isoprenaline hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoprenaline hydrochloride, dl- | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoprenaline sulfate | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoprenaline sulfate dihydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoprenaline sulphate | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoprenalini sulfas | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isopropydrin | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoproterenol dl-form | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoproterenol dl-form hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoproterenol dl-form sulfate dihydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoproterenol hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoproterenol Hydrochloride | “Drug: Isoproterenol Hydrochloride” NCT05997732 ↗ |
| Known as | Isoproterenol hydrochloride component of duo-medihaler | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | ISOPROTERENOL SULFATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoproterenol sulfate anhydrous | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoproterenol sulfate dihydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isoproterenol sulphate | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isorenin | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isovon | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isuprel | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Isupren | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Medihaler-iso | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Mistarel | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Neo-epinine | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Neodrenal | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Norisodrine | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Norisodrine aerotrol | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Novodrin | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | NSC-33791 | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | NSC-37745 | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | NSC-89747 | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | NSC-9975 | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Oriconazole | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Propal | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Proternol | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Respifral | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Saventrine | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Suscardia | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Vapo-iso | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Known as | Vapo-n-iso | ChEMBL registry synonym — accepted as the source's own label CHEMBL434 ↗ |
| Action | Activate | “Isoproterenol is a direct acting Beta-1 and Beta-2 agonist useful for its effects on bronchodilation and myocardial contractility.” NCT01377636 ↗ |
| Modality | Small molecule | “synthetic β agonist (isoproterenol) infusion model” PMID 40311885 ↗ Apr 2025 |
| Route | Other | “endoluminally administrated isoproterenol” NCT00428428 ↗ |